Therapy-related acute myeloid leukaemia after successful therapy for acute promyelocytic leukaemia with t(15;17): a report of two cases and a review of the literature.

Abstract

We describe two patients with positive t(15;17) acute promyelocytic leukaemia (APL) that developed into a therapy-related myelodysplasia 2-2.5 years after complete remission (CR) and then evolved into therapy-related acute myeloid leukaemia (t-AML). Both patients received anthracyclines as potential leukaemogenic drugs. In both cases, cytogenetic changes usually occurring after use of alkylating agents were noticed: monosomy 7 associated with monosomy 5 or 5q- chromosome. A review of the literature on t-AML occurring after successful therapy for APL showed only one report similar to these two cases. These observations suggest that anthracyclines can cause t-AML similar to that induced by alkylating agents.

• Authors: S Zompi, O Legrand, D Bouscary, C M Blanc, F Picard, N Casadevall, F Dreyfus, J P Marie, F Viguié
• Journal: British journal of haematology (Br J Haematol) Vol. 110 Issue 3 Pg. 610-3 (Sep 2000) ISSN: 0007-1048 [Print] England
• PMID: 10997972 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibiotics, Antineoplastic

Topics

• Adult
• Antibiotics, Antineoplastic (adverse effects, therapeutic use)
• Child
• Chromosomes, Human, Pair 15
• Chromosomes, Human, Pair 17
• Chromosomes, Human, Pair 5
• Chromosomes, Human, Pair 7
• Female
• Humans
• Karyotyping
• Leukemia, Myeloid (chemically induced, complications, genetics)
• Leukemia, Promyelocytic, Acute (complications, drug therapy, genetics)
• Male
• Middle Aged
• Monosomy
• Recurrence
• Translocation, Genetic