[Increased prevalence of APC-resistance (factor V Leiden mutation) in patients with postthrombotic syndrome].

Abstract

BACKGROUND AND OBJECTIVE:

APC resistance (Factor V Leiden mutation) is the most often diagnosed hereditary thrombolytic defect. Data about the prevalence in patients with leg ulcers, especially postthrombosis, are limited of this defect.

PATIENTS/METHODS:

APC resistance was determined in 100 patients with venous leg ulcers. 53 patients had ulcers caused by postthrombotic syndrome and 47 patients ulcers associated with primary varicosities. A control group of 96 healthy volunteers was also studied.

RESULTS:

19 of 53 patients (36%) with postthrombotic ulcers and 3 of 47 patients (6%) with varicosity-related ulcers had APC resistance. In the control group APC resistance was detected in 5 of 96 volunteers (5%).

CONCLUSIONS:

APC resistance should be considered as a risk factor for the development of venous leg ulcers.

• Authors: Y Gaber, H J Siemens, W Schmeller
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 51 Issue 8 Pg. 590-2 (Aug 2000) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Hohe Prävalenz der APC-Resistenz (Faktor-V-Leiden-Mutation) bei Patienten mit postthrombotischem Syndrom.
• PMID: 10997314 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Factor V

Topics

• Activated Protein C Resistance (complications, epidemiology, etiology)
• Adult
• Aged
• Aged, 80 and over
• Cross-Sectional Studies
• Factor V (genetics)
• Female
• Humans
• Leg Ulcer (etiology)
• Male
• Middle Aged
• Mutation
• Postphlebitic Syndrome (complications, etiology)