The association between vascular endothelial growth factor, microvessel density and clinicopathological features in invasive cervical cancer.

Abstract

OBJECTIVE:

The aim of this study was to analyse the vascular endothelial growth factor (VEGF) expression in a series of cervical carcinomas and to compare the results with the microvessel density (MVD) and clinicopathological features.

STUDY DESIGN:

The immunoreactivity for VEGF was studied in 130 invasive cervical carcinomas and in 22 patients with a carcinoma in situ of the cervix. The results were compared with the MVD.

RESULTS:

Staining for VEGF of less then 50% per slide occurred in 80% of the invasive carcinomas and in 82% of the in situ carcinomas. The median MVD was 261 vv/mm(2) (range: 11-1000) in the invasive group and 146 vv/mm(2) (range: 25-536) in the in situ group. Unlike the microvessel density there was no association between VEGF expression and survival. The MVD was higher in VEGF poorer (<50%) tumours (P=0.055). Beside tumour histology (P=0.012) there were no other significant relationships between the remaining histopathological findings and VEGF expression.

CONCLUSION:

Tissue VEGF expression has no prognostic value in contrast with the MVD in patients with invasive cervical cancer.

• Authors: W Tjalma, J Weyler, B Weyn, E Van Marck, A Van Daele, P Van Dam, G Goovaerts, P Buytaert
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 92 Issue 2 Pg. 251-7 (Oct 2000) ISSN: 0301-2115 [Print] Ireland
• PMID: 10996690 (Publication Type: Journal Article)

Chemical References

• Endothelial Growth Factors
• Lymphokines
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors

Topics

• Adenocarcinoma (blood supply, chemistry, pathology)
• Adult
• Aged
• Carcinoma, Adenosquamous (blood supply, chemistry, pathology)
• Carcinoma, Squamous Cell (blood supply, chemistry, pathology)
• Endothelial Growth Factors (analysis)
• Female
• Humans
• Immunohistochemistry
• Lymphokines (analysis)
• Microcirculation (pathology)
• Middle Aged
• Prognosis
• Uterine Cervical Neoplasms (blood supply, chemistry, pathology)
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factors