Cefodizime in skin suction blister fluid and serum following a single intravenous or intramuscular dose in adult patients.

Abstract

Cefodizime is a third generation cephalosporin for parenteral use. The pharmacokinetics of this cephem antibiotic were determined in serum and skin suction blister fluid (SBF) after intravenous (i.v.) or intramuscular (i.m.) administration of a single 1 g dose in 8 adult patients with normal renal and hepatic function who volunteered for the study. The concentration versus time curve showed a slower elimination rate from the extravascular compartment: the half-lives were 4.4+/-0.5 and 5.4+/-0.4 hours after i.v. and i.m. route respectively. The relatively long elimination half-life in SBF with a mean residence time of about 8 hours allows the use of cefodizime once-a-day for the treatment of infections due to sensitive pathogens.

• Authors: T Mazzei, A Novelli, S Esposito, S Fallani, S Noviello, M I Cassetta, S Conti, P Periti
• Journal: Journal of chemotherapy (Florence, Italy) (J Chemother) Vol. 12 Issue 4 Pg. 306-13 (Aug 2000) ISSN: 1120-009X [Print] England
• PMID: 10949980 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Cephalosporins
• Cefotaxime
• cefodizime

Topics

• Adult
• Blister (metabolism)
• Body Fluids (metabolism)
• Cefotaxime (analogs & derivatives, blood, pharmacokinetics)
• Cephalosporins (blood, pharmacokinetics)
• Humans
• Infusions, Intravenous
• Injections, Intramuscular
• Kidney Function Tests
• Liver Function Tests
• Male
• Respiratory Tract Diseases (blood, metabolism)
• Skin (metabolism)
• Suction