Efficacy of FK463, a (1,3)-beta-D-glucan synthase inhibitor, in disseminated azole-resistant candida albicans infection in mice.

Abstract

The efficacy of FK463, a new (1,3)-beta-D-glucan synthase inhibitor, against azole-resistant Candida albicans strains has been studied. The MIC of FK463 was lower than those of azoles and amphotericin B against CDR1-expressing C26 and CaMDR-expressing C40 strains. All mice treated with FK463 (1 mg/kg) survived disseminated murine candidiasis. The fungal burden in the kidney after 6 days was markedly reduced after therapy with FK463 and amphotericin B sodium deoxycholate, and plasma (1,3)-beta-D-glucan concentration was found to be lower in FK463-treated mice. In our study, FK463 was found to be a potent antifungal agent against disseminated infection with azole-resistant C. albicans.

• Authors: S Maesaki, M A Hossain, Y Miyazaki, K Tomono, T Tashiro, S Kohno
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 44 Issue 6 Pg. 1728-30 (Jun 2000) ISSN: 0066-4804 [Print] United States
• PMID: 10817741 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Azoles
• Echinocandins
• Lipopeptides
• Lipoproteins
• Peptides, Cyclic
• Micafungin

Topics

• Animals
• Antifungal Agents (pharmacology, therapeutic use)
• Azoles (pharmacology)
• Candida albicans (drug effects)
• Candidiasis (drug therapy)
• Drug Resistance, Microbial
• Echinocandins
• Lipopeptides
• Lipoproteins (pharmacology, therapeutic use)
• Micafungin
• Mice
• Peptides, Cyclic (pharmacology, therapeutic use)