Abstract |
This report presents changes of IGFs and IGFBPs in a female infant with partial trisomy 9q in the 12th week of life. Studying deficient growth in this hypoplastic infant ( birth weight 1405 g, birth length 36 cm) with dysmorphic features, the following changes in IGFs and IGFBPs were detected (microg/l): IGF-I: 26.5 vs 48.1 in healthy infants; IGF-II: 420 vs 728; IGFBP-2: 931 vs 524; IGFBP-3: 800 vs 1070. This demonstrates that IGFs and IGFBPs may reflect individual insufficient growth even at this early age.
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Authors | A Hübler, J Seidel, E Kauf, D Schramm, V Beensen, A Heller, T Liehr, F Zintl |
Journal | Journal of pediatric endocrinology & metabolism : JPEM
(J Pediatr Endocrinol Metab)
Vol. 13
Issue 4
Pg. 445-50
(Apr 2000)
ISSN: 0334-018X [Print] Germany |
PMID | 10777002
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Insulin-Like Growth Factor Binding Protein 2
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Insulin-Like Growth Factor II
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Topics |
- Adult
- Chromosomes, Human, Pair 9
- Craniofacial Abnormalities
(genetics)
- Female
- Fetal Growth Retardation
(genetics)
- Growth Disorders
(genetics)
- Humans
- Hypothyroidism
(genetics)
- Infant
- Insulin-Like Growth Factor Binding Protein 2
(blood)
- Insulin-Like Growth Factor Binding Protein 3
(blood)
- Insulin-Like Growth Factor I
(deficiency)
- Insulin-Like Growth Factor II
(deficiency)
- Karyotyping
- Pregnancy
- Trisomy
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