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Treatment of Old World cutaneous leishmaniasis by pentamidine isethionate. An open study of 11 patients.

AbstractBACKGROUND:
Pentavalent antimonial derivatives (PAD), especially meglumine antimoniate (Glucantime((R))), are usually considered as the first-line drugs for Old World leishmaniasis, but their potential toxicity and the number of required injection, either intralesional or intramuscular, prompt to search for alternative treatments.
OBJECTIVE:
To evaluate the efficiency and tolerance of pentamidine isethionate in Old World leishmaniasis.
METHODS:
An open pilot study included 11 patients from two regional academic centers, with varied parasitological forms of Old World leishmaniasis, treated with three strictly intramuscular injections of 4 mg/kg of base-pentamidine every other day.
RESULTS:
Tolerance was good overall, and 8/11 (73%) of patients responded well with a quick healing of their lesions, little scarring and no relapse.
CONCLUSION:
Pentamidine isethionate is a safe and effective first-line treatment for Old World leishmaniasis. Larger-scale prospective studies comparing several dosage regimens of pentamidine and pentamidine isethionate to PAD are warranted.
AuthorsI Hellier, O Dereure, I Tournillac, F Pratlong, B Guillot, J P Dedet, J J Guilhou
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 200 Issue 2 Pg. 120-3 ( 2000) ISSN: 1018-8665 [Print] SWITZERLAND
PMID10773699 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)
CopyrightCopyright 2000 S. Karger AG, Basel.
Chemical References
  • Antiprotozoal Agents
  • Pentamidine
Topics
  • Adolescent
  • Adult
  • Aged
  • Antiprotozoal Agents (adverse effects, therapeutic use)
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Leishmaniasis, Cutaneous (drug therapy)
  • Male
  • Middle Aged
  • Pentamidine (adverse effects, therapeutic use)
  • Pilot Projects
  • Prospective Studies

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