Cytotoxic effects of pyridino[2,3-f]indole-4,9-diones on human tumor cell lines.

Abstract

The cytotoxicities of pyridino[2,3-f]indole-4,9-dione derivatives were examined against human lung tumor cell lines (A 549), human ovarian tumor cell lines (SK-OV-3), human melanoma tumor cell lines (SK-MEL-2), human CNS tumor cell lines (XF 498) and human colon tumor cell lines (HCT 15) in vitro using a Sulforhodamine B assay. 3-Ethoxycarbonyl-1-(2-methoxyethyl)-2-methyl-1H-pyridino[2,3-f]ind ole-4,9-dione (5) showed excellent cytotoxicity against XF 498 and HCT 15. The ED50 values of 5 were 0.006 microg/ml against XF 498 and 0.073 microg/ml against HCT 15, while those of doxorubicin were 0.012 and 0.264 microg/ml, respectively. 1-Benzyl-3-ethoxycarbonyl-2-methyl-1H-pyridino[2,3-f]indole-4,9-di one (7) (ED50 value 0.065 microg/ml) was also significantly more cytotoxic against HCT 15 compared with doxorubicin.

• Authors: M E Suh, H K Park, H W Yoo, C O Lee
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 23 Issue 3 Pg. 354-5 (Mar 2000) ISSN: 0918-6158 [Print] Japan
• PMID: 10726894 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Indoles
• Pyridines

Topics

• Antineoplastic Agents (pharmacology)
• Cell Division (drug effects)
• Drug Screening Assays, Antitumor
• Humans
• Indoles (pharmacology)
• Pyridines (pharmacology)
• Tumor Cells, Cultured