111In-pentetreotide scintigraphy in the detection of insulinomas: importance of SPECT imaging.

Abstract

UNLABELLED:

The aim of this study was to determine whether the systematic use of SPECT can increase the reported low sensitivity of somatostatin receptor scintigraphy (SRS) in detecting insulinomas.

METHODS:

Fourteen patients were evaluated. After 111In-pentetreotide injection (approximately 250 MBq intravenously), abdominal SPECT images were obtained at 4 h and multiple planar images were obtained at 4 and 24 h. MRI and CT were performed within 1 mo of SRS. Sixteen tumors were histologically verified after surgery in 14 patients.

RESULTS:

SPECT revealed 14 lesions in 12 patients (sensitivity, 87.5%), both planar SRS and MRI revealed 7 tumors in 7 patients (sensitivity, 43.8%), and CT revealed only 5 lesions in 4 patients (sensitivity, 31.3%). Moreover, in 4 patients SPECT was the only examination with positive findings.

CONCLUSION:

SPECT at 4 h is mandatory for preoperative detection of insulinomas using SRS because the images are more sensitive than planar images and are superior to images from other conventional methods.

• Authors: O Schillaci, R Massa, F Scopinaro
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 41 Issue 3 Pg. 459-62 (Mar 2000) ISSN: 0161-5505 [Print] United States
• PMID: 10716319 (Publication Type: Journal Article)

Chemical References

• Indium Radioisotopes
• Receptors, Somatostatin
• Somatostatin
• pentetreotide

Topics

• Female
• Humans
• Indium Radioisotopes
• Insulinoma (diagnostic imaging)
• Male
• Middle Aged
• Pancreatic Neoplasms (diagnostic imaging)
• Prospective Studies
• Receptors, Somatostatin (metabolism)
• Sensitivity and Specificity
• Somatostatin (analogs & derivatives)
• Tomography, Emission-Computed, Single-Photon