Selective effect of cyclosporine monotherapy for pure red cell aplasia not associated with granular lymphocyte-proliferative disorders.

Abstract

Morphological characteristics of lymphocytes and the response to cyclosporine treatment have revealed some unique patients with pure red cell aplasia. Lymphocytes from these patients consisted mainly of non-granulated lymphocytes. All of the patients were successfully managed by cyclosporine monotherapy irrespective of prior treatment. A reduction in lymphocyte mass was not a prerequisite for the remission of pure red cell aplasia, and responses occurred within 1 month from the start of therapy. Clonal T-cell proliferation was detected in four patients, which raised the possibility of idiopathic pure red cell aplasia being associated with a clonal proliferation of T cells. An examination of the lymphocytes in patients with pure red cell aplasia could potentially be used to plan better therapeutic modalities and assess prognosis.

• Authors: O Yamada, T Motoji, H Mizoguchi
• Journal: British journal of haematology (Br J Haematol) Vol. 106 Issue 2 Pg. 371-6 (Aug 1999) ISSN: 0007-1048 [Print] England
• PMID: 10460593 (Publication Type: Journal Article)

Chemical References

• Cyclosporine

Topics

• Adult
• Aged
• Cell Division
• Cyclosporine (therapeutic use)
• Female
• Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
• Humans
• Leukocytes, Mononuclear (pathology)
• Male
• Middle Aged
• Phenotype
• Red-Cell Aplasia, Pure (drug therapy, genetics)
• T-Lymphocytes (pathology)
• Treatment Outcome