Abstract | OBJECTIVES: METHODS: RESULTS: CONCLUSION: CLINICAL RELEVANCE: Because up-regulation and activation of proteinases represents a final common pathway in the process of retinal neovascularization, pharmacological intervention of this pathway may be an alternative therapeutic approach to proliferative retinopathy.
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Authors | A Das, A McLamore, W Song, P G McGuire |
Journal | Archives of ophthalmology (Chicago, Ill. : 1960)
(Arch Ophthalmol)
Vol. 117
Issue 4
Pg. 498-503
(Apr 1999)
ISSN: 0003-9950 [Print] United States |
PMID | 10206578
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Protease Inhibitors
- Thiophenes
- Phenylalanine
- batimastat
- Urokinase-Type Plasminogen Activator
- Collagenases
- Gelatinases
- Metalloendopeptidases
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
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Topics |
- Animals
- Animals, Newborn
- Collagenases
(metabolism)
- Disease Models, Animal
- Gelatinases
(metabolism)
- Injections, Intraperitoneal
- Ischemia
(complications)
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Metalloendopeptidases
(antagonists & inhibitors, metabolism)
- Mice
- Mice, Inbred C57BL
- Phenylalanine
(analogs & derivatives, pharmacology)
- Protease Inhibitors
(pharmacology)
- Retina
(drug effects, enzymology, pathology)
- Retinal Neovascularization
(enzymology, etiology, pathology, prevention & control)
- Retinal Vessels
(drug effects, pathology)
- Thiophenes
(pharmacology)
- Urokinase-Type Plasminogen Activator
(metabolism)
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