muqubilin A

a cyclic peroxide norterpene from a marine sponge

Also Known As:

(2S)-2-((3R,6S)-6-Methyl-6-((3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexen-1-yl)-1,2-dioxan-3-yl)propanoic acid; 1,2-dioxane-3-acetic acid, alpha,6-dimethyl-6-((3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexen-1-yl)-, (alphaS,3R,6S)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ciavatta, Maria Letizia: 1 article (09/2013)
2.	Fakhr, Issa: 1 article (09/2013)
3.	Hamdy, Nehal Aly: 1 article (09/2013)
4.	Kiss, Robert: 1 article (09/2013)
5.	Lefranc, Florence: 1 article (09/2013)
6.	Mathieu, Véronique: 1 article (09/2013)
7.	Moreno Y Banuls, Laetitia: 1 article (09/2013)
8.	Nuzzo, Genoveffa: 1 article (09/2013)
9.	Van Goietsenoven, Gwendoline: 1 article (09/2013)
10.	Villani, Guido: 1 article (09/2013)

Related Diseases

Neoplasms (Cancer)

09/27/2013 - "Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells."
09/27/2013 - "Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC₅₀ growth inhibitory concentrations in vitro of <10 μM, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. "