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LC-0296

Histone Deacetylase Inhibitors; structure in first source

Also Known As:

2-(((benzyloxy)carbonyl)amino)-5-((1-(3-carbamoylbenzyl)-1H-indol-4-yl)amino)-5-oxopentanoate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - LC-0296: 1
  - 4 or More Rings Heterocyclic Compounds
    - LC-0296: 1

Experts

1.	Ai, Teng: 1 article (01/2016)
2.	Alhazzazi, Turki Y: 1 article (01/2016)
3.	Chen, Liqiang: 1 article (01/2016)
4.	Kamarajan, Pachiyappan: 1 article (01/2016)
5.	Kapila, Yvonne L: 1 article (01/2016)
6.	Verdin, Eric: 1 article (01/2016)
7.	Xu, Yanli: 1 article (01/2016)

Related Diseases

1.	Head and Neck Neoplasms (Head and Neck Cancer) 01/01/2016 - "A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells." 01/01/2016 - "Development of novel SIRT3 inhibitors, such as LC-0296, might enable the development of new targeted therapies to treat and improve the survival rate of patients with head and neck cancer."
2.	Squamous Cell Carcinoma of Head and Neck 01/01/2016 - "LC-0296 reduces cell proliferation and promotes apoptosis of HNSCC cells but not of normal human oral keratinocytes. " 01/01/2016 - "Additionally, LC-0296 works synergistically to increase the sensitivity of HNSCC cells to radiation and cisplatin treatment. " 01/01/2016 - "The effect of the SIRT3 inhibitor, LC-0296, on cell survival, proliferation, and apoptosis, and reactive oxygen species levels in HNSCC cells were studied. "

Related Drugs and Biologics

1.	Sirtuin 3
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Therapeutics