1-Alkyl-2-acetylglycerophosphocholine Esterase

A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

Also Known As:

PAF Acetylhydrolase; Lipoprotein-Associated Phospholipase A(2); Lipoprotein-Associated Phospholipase A2; Lp-PLA(2); Lp-PLA2; PAF 2-Acetylhydrolase; PAF 2-Acylhydrolase; PAF Acetylhydrolase II; Platelet-activating Factor Acetylhydrolase IB; 1 Alkyl 2 acetylglycerophosphocholine Esterase; 2-Acetylhydrolase, PAF; Acetylhydrolase II, PAF; Acetylhydrolase, PAF; Esterase, 1-Alkyl-2-acetylglycerophosphocholine; Factor Hydrolase, Platelet-Activating; Hydrolase, Platelet-Activating Factor; Lipoprotein Associated Phospholipase A2; Lp PLA2; PAF 2 Acetylhydrolase; PAF 2 Acylhydrolase; Phospholipase A2, Lipoprotein-Associated; Platelet Activating Factor Hydrolase; Platelet activating Factor Acetylhydrolase IB; Platelet-Activating Factor Hydrolase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Esterases: 1594
      - Carboxylic Ester Hydrolases: 64
        Phospholipases: 2616
        Phospholipases A: 58
        Phospholipases A2: 2112
        1-Alkyl-2-acetylglycerophosphocholine Esterase: 1010

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Disease

Drug/Important Bio-Agent (IBA)