Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera.

Abstract

As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas coniferacollected from Belize. The structure of debromosceptrin was identified by analysis of spectral data. 15N spectral data assignments were made for compounds 1-3. Compounds 2 and 3 showed marginal inhibition of Mycobacterium tuberculosis.

• Authors: X Shen, T L Perry, C D Dunbar, M Kelly-Borges, M T Hamann
• Journal: Journal of natural products (J Nat Prod) Vol. 61 Issue 10 Pg. 1302-3 (Oct 1998) ISSN: 0163-3864 [Print] United States
• PMID: 9784176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antitubercular Agents
• Pyrroles
• debromosceptrin

Topics

• Animals
• Antitubercular Agents (chemistry, isolation & purification, pharmacology)
• HIV (drug effects)
• Magnetic Resonance Spectroscopy
• Microbial Sensitivity Tests
• Molecular Structure
• Mycobacterium tuberculosis (drug effects)
• Porifera (chemistry)
• Pyrroles (chemistry, isolation & purification, pharmacology)