Abstract | BACKGROUND: MATERIALS: RESULTS: A class of guanidinobenzoatase positive cells was observed in the original human astrocytomas and in tumor masses formed in the implantation pocket and around blood vessels. Secondary foci containing guanidinobenzoatase positive cells formed around blood vessels and individual positive astrocytoma cells migrated on the glia limitans along parallel and intersecting nerve fiber fascicles and the corpus callosum. uPA and GFAP were colocalized with guanidinobenzoatase. CONCLUSION: The high-grade astrocytomas reestablish themselves and maintain their characteristics as a tissue although grafted as individual cells.
|
Authors | L J Bernstein, J C Tonn, R H Goldbrunner, G H Vince, S Wagner, W J Goldberg |
Journal | Anticancer research
(Anticancer Res)
1998 Jul-Aug
Vol. 18
Issue 4A
Pg. 2583-90
ISSN: 0250-7005 [Print] Greece |
PMID | 9703913
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Carboxylic Ester Hydrolases
- guanidinobenzoate esterase
- Endopeptidases
- Urokinase-Type Plasminogen Activator
|
Topics |
- Animals
- Astrocytoma
(blood supply, enzymology, pathology)
- Brain Neoplasms
(blood supply, enzymology, pathology)
- Carboxylic Ester Hydrolases
(analysis)
- Cerebrovascular Circulation
- Disease Progression
- Endopeptidases
(analysis)
- Glioblastoma
(blood supply, enzymology, pathology)
- Humans
- Male
- Microscopy, Confocal
- Neoplasm Metastasis
- Rats
- Rats, Nude
- Transplantation, Heterologous
- Tumor Cells, Cultured
- Urokinase-Type Plasminogen Activator
(analysis)
|