Astrocytoma (Pilocytic Astrocytoma)

4010  relevant articles (119 outcomes, 581 trials/studies) found for this Disease

Pilocytic Astrocytoma; Anaplastic Astrocytoma; Juvenile Pilocytic Astrocytoma; Subependymal Giant Cell Astrocytoma; Astrocytoma, Grade I; Astrocytoma, Grade II; Astrocytoma, Grade III; Astrocytoma, Protoplasmic; Astroglioma; Cerebral Astrocytoma; Childhood Cerebral Astrocytoma; Fibrillary Astrocytoma; Gemistocytic Astrocytoma; Intracranial Astrocytoma; Anaplastic Astrocytomas; Astrocytic Glioma; Astrocytic Gliomas; Astrocytoma, Anaplastic; Astrocytoma, Cerebral; Astrocytoma, Childhood Cerebral; Astrocytoma, Fibrillary; Astrocytoma, Gemistocytic; Astrocytoma, Intracranial; Astrocytoma, Juvenile Pilocytic; Astrocytoma, Pilocytic; Astrocytomas; Astrocytomas, Anaplastic; Astrocytomas, Cerebral; Astrocytomas, Childhood Cerebral; Astrocytomas, Fibrillary; Astrocytomas, Gemistocytic; Astrocytomas, Grade I; Astrocytomas, Grade II; Astrocytomas, Grade III; Astrocytomas, Intracranial; Astrocytomas, Juvenile Pilocytic; Astrocytomas, Pilocytic; Astrocytomas, Protoplasmic; Astrogliomas; Cerebral Astrocytoma, Childhood; Cerebral Astrocytomas; Cerebral Astrocytomas, Childhood; Childhood Cerebral Astrocytomas; Fibrillary Astrocytomas; Gemistocytic Astrocytomas; Gliomas, Astrocytic; Grade I Astrocytoma; Grade I Astrocytomas; Grade II Astrocytoma; Grade II Astrocytomas; Grade III Astrocytoma; Grade III Astrocytomas; Intracranial Astrocytomas; Juvenile Pilocytic Astrocytomas; Mixed Oligoastrocytoma; Mixed Oligoastrocytomas; Oligoastrocytomas, Mixed; Pilocytic Astrocytoma, Juvenile; Pilocytic Astrocytomas; Pilocytic Astrocytomas, Juvenile; Protoplasmic Astrocytoma; Protoplasmic Astrocytomas; Astrocytoma, Subependymal Giant Cell; Glioma, Astrocytic; Oligoastrocytoma, Mixed

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme)
2.	Neoplasms (Cancer)
3.	Astrocytoma (Pilocytic Astrocytoma)
4.	Glioma (Gliomas)
5.	Oligodendroglioma

Experts

1.	Yoshino, Atsuo: 8 articles (02/2007 - 12/2002)
2.	Katayama, Yoichi: 8 articles (02/2007 - 12/2002)
3.	Watanabe, Takao: 8 articles (02/2007 - 12/2002)
4.	Guha, Abhijit: 7 articles (02/2007 - 10/2002)
5.	Nakahata, Norimichi: 6 articles (09/2008 - 05/2002)
6.	Shields, Carol L: 6 articles (06/2008 - 01/2004)
7.	Rutka, James T: 6 articles (05/2008 - 10/2002)
8.	Fukushima, Takao: 6 articles (02/2007 - 12/2002)
9.	Benveniste, Etty N: 6 articles (07/2006 - 02/2002)
10.	Shields, Jerry A: 5 articles (06/2008 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Astrocytoma:

1.	temozolomide (Temodar)FDA Link 09/01/2006 - "The patient is currently alive but with recurrent astrocytoma after a complete remission on temozolomide monotherapy. " 08/01/2001 - "A large, multicenter, single-arm trial (N = 162) showed an impressive response rate for patients with relapsed anaplastic astrocytoma receiving temozolomide, and patients maintained or improved their quality of life compared with baseline values. " 09/01/2000 - "One of the objectives of this phase II study was to determine whether temozolomide (TMZ) improved the health-related quality of life (HRQL) of patients with recurrent anaplastic astrocytoma (AA). " 07/01/2000 - "Temodar offers promise for treating astrocytomas." 09/01/2006 - "[Efficacy and safety of monotherapy with temozolomide in patients with anaplastic astrocytoma at first relapse--a phase II clinical study]" Order ALL the reference details at left...
2.	Etoposide (VP 16)FDA LinkGeneric 04/01/1997 - "Oral etoposide was well tolerated, produced modest toxicity, and had apparent activity in this small cohort of children with recurrent juvenile pilocytic cerebellar astrocytomas." 04/01/1997 - "The purpose of this investigation was to assess the toxicity and activity of chronic oral etoposide in the management of children with recurrent juvenile pilocytic cerebellar astrocytomas. " 04/01/1997 - "Twelve children with recurrent juvenile pilocytic cerebellar astrocytomas, refractory to surgical resection, radiotherapy, and chemotherapy were treated with chronic oral etoposide. " 01/01/1999 - "CONCLUSION: Intravenous etoposide has a low level of activity in the treatment of recurrent low grade astrocytomas and medulloblastoma or PNET. " 02/01/1996 - "Prolonged low-dose oral VP16 is modestly effective treatment for patients with recurrent malignant glioma and is more effective for anaplastic astrocytoma and anaplastic oligodendroglioma than glioblastoma multiforme." Order ALL the reference details at left...
3.	Carboplatin (JM8)FDA LinkGeneric 05/01/2002 - "In our study, we describe clinical features and diagnostic procedures of carboplatin-associated reactions in children affected by low-grade astrocytoma and treated with multiple courses of carboplatin. " 02/01/1996 - "Both boys continued therapy with carboplatin; their astrocytomas are stable and they are clinically well. " 09/01/2005 - "Spinal leptomeningeal biopsy revealed a pilocytic astrocytoma WHO grade I. Despite chemotherapy with vincristin and carboplatin, the patient died 2 months after admission. " 11/01/1996 - "CASE REPORT: An 8-year-old boy was treated for an astrocytoma by monthly intravenous injections of carboplatin. " 02/01/1996 - "Carboplatin is the drug of choice for the treatment of nonresectable astrocytomas in children, but patients who are intolerant may require cranial irradiation which is associated with significant morbidity. " Order ALL the reference details at left...
4.	Carmustine (FIVB)FDA Link 10/01/1998 - "PATIENTS AND METHODS: We correlated the MGMT level in malignant astrocytoma tissues, obtained from patients treated with radiotherapy and bis-chloroethylnitrosourea (BCNU) on a prior prospective trial (Southwest Oncology Group [SWOG] 8737), with overall and failure-free survival. " 07/01/1997 - "CONCLUSION: This trial found no evidence of differences in treatment efficacy when either DBD or BCNU is combined with radiation therapy for patients with high-grade astrocytoma." 07/01/1997 - "PURPOSE: We performed a randomized trial to compare survival distributions and toxicity of radiation therapy (RT) and DBD with RT and BCNU in patients with high-grade astrocytoma. " 04/01/1978 - "A microtiter assay was used to study the sensitivity of 24 cultured human astrocytomas to the chemotherapeutic agent 1,3-bis(2-chloroethyl)-1 nitrosourea (BCNU). " 09/01/2005 - "These findings suggest that enhanced sensitivity to BCNU and TMZ is a general property of human astrocytic glioma cells in which p53 was disrupted. " Order ALL the reference details at left...
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/01/2004 - "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptotic cell death as well as expression of proinflammatory genes such as CXCL8 in malignant human astrocytoma cells. " 06/01/2003 - "P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis." 12/01/2002 - "We have investigated the potential of PAR2 agonists to modulate TNF-alpha secretion from human astrocytoma cell line CCF-STTG1. " 12/10/2000 - "Since ceramide is an important regulatory molecule of programmed cell death induced by TNF-alpha, we examined whether nef could alter TNF-alpha-induced apoptosis in the U251MG human astrocytoma cell line. " 12/01/2000 - "In contrast, pronounced production of Abeta1-40 and Abeta1-42 was observed when primary astrocytes or astrocytoma cells were stimulated with combinations of IFNgamma and TNFalpha or IFNgamma and IL-1beta. " Order ALL the reference details at left...
6.	Paclitaxel (Taxol)FDA LinkGeneric 02/01/1996 - "Paclitaxel has shown antitumor efficacy against astrocytoma cell lines, and is a potent radiosensitizer. " 03/01/2004 - "The authors investigated the safety and efficacy of intratumoral convection-enhanced delivery (CED) of paclitaxel in patients harboring histologically confirmed recurrent GBMs and anaplastic astrocytomas. " 05/01/1999 - "CONCLUSIONS: Taxol demonstrated modest efficacy with manageable toxicity in this heavily pre-treated cohort of young adult patients with recurrent anaplastic astrocytomas." 09/01/2001 - "Preclinical studies indicate synergy between RT and paclitaxel (TAX) in astrocytoma cell lines. " 05/01/1999 - "BACKGROUND: A prospective Phase II study of Taxol in young adult patients with recurrent anaplastic astrocytomas. " Order ALL the reference details at left...
7.	Amphotericin B (Amphotericin)FDA LinkGeneric 05/01/1970 - "Remission of grade 3 astrocytoma after irradiation and amphotericin B." 05/01/1970 - "Remission of grade 3 astrocytoma after irradiation and amphotericin B." 03/14/1970 - "Remission of astrocytoma following amphotericin-B treatment." 10/27/1973 - "Letter: Amphotericin B in astrocytoma." Order ALL the reference details at left...
8.	DNA (Deoxyribonucleic Acid)IBA 07/01/2009 - "In the present study, DNA from 28 pediatric low-grade astrocytomas was analyzed using Illumina HumanHap550K single-nucleotide polymorphism oligonucleotide arrays. " 06/01/2002 - "This study was extended by sequencing 10 DNA samples of diffuse astrocytomas (World Health Organisation grade II) and corresponding blood samples. " 10/01/1995 - "STUDY DESIGN: A nested polymerase chain reaction (PCR) was used for the detection of JCV DNA in autopsy brain material (cerebral white matter) and cerebrospinal fluid (CSF) specimens from patients with AD and age-matched control patients without neurological diseases, together with biopsies from patients with astrocytomas (grades 3 and 4). " 09/01/1991 - "[Quantitative study on DNA content and nucleolar organiser regions in astrocytoma]" 10/01/1988 - "The case of a 1-year-old girl with primary malignant astrocytoma of the cerebellum is presented with special reference to ultramicroscopic study and cytofluorometric DNA analysis. " Order ALL the reference details at left...
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/01/2004 - "The aim of this study was to determine the relation of HIF-1alpha to vascular endothelial growth factor (VEGF; an important angiogenic molecule in brain tumours), p53 expression, angiogenesis, proliferative potential and clinical outcome in a large series of diffuse astrocytomas. " 09/01/2003 - "There are no studies correlating molecular changes of PTEN and the immunohistochemical expression of its protein (pPTEN) with the expression of vascular endothelial growth factor (VEGF) in astrocytomas. " 02/01/2001 - "METHODS: Immunohistochemistry, semiquantitation and image analysis were used to study the expression features of VEGF and iNOS in 61 cases of astrocytomas having follow-up data. " 01/01/2009 - "Higher expression of VEGF in high grade astrocytomas may subsequently lead to activation of survival, angiogenesis and migration. " 12/01/2008 - "Furthermore, we studied the involvement of HuR in the upregulation of VEGF-A expression using malignant astrocytoma cell lines. " Order ALL the reference details at left...
10.	Vincristine (Oncovin)FDA LinkGeneric 01/01/1988 - "Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma." 08/01/1976 - "Eight of the 16 patients who received four or more doses of vincristine showed significant objective responses; these included patients with high-and low-grade astrocytomas and patients with medulloblastoma. " 11/01/2004 - "Carboplatin and vincristine appeared to be effective, safe therapy for those with low-grade astrocytomas of the cord." 07/01/2007 - "Protocol IV (vincristine and carboplatin) in 4 children with astrocytoma fibrillare and astrocytoma pilocyticum. " 01/01/2007 - "The second patient was a 19-month-old boy with a C3-T4 grade II intramedullary astrocytoma who received up-front vincristine and carboplatin for two months but remained clinically symptomatic. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/15/1995 - "Chemotherapy appears to be effective primary adjuvant treatment for some very young children with anaplastic astrocytomas. " 01/01/1994 - "The study suggests that malignant astrocytoma can be successfully eradicated with surgery, irradiation, IFN-alpha and chemotherapy. " 07/01/2007 - "Based on randomized data available, chemotherapy has consistently failed to improve the outcome of patients with anaplastic astrocytoma, while a meta-analysis showed a small, but significant improvement in survival favouring the use of chemotherapy. " 05/01/2001 - "CLINICAL PRESENTATION: t-MDS developed four and one-half years after successful therapy (resection, radiation and chemotherapy) administered for a cerebral anaplastic astrocytoma in a 34-year-old patient. " 06/01/2000 - "BACKGROUND: For more than 20 years, after establishing the role of postoperative radiotherapy for malignant astrocytomas, no definitive improvement in survival rates could be observed, despite advances in established treatment modalities such as radiotherapy and chemotherapy. " Order ALL the reference details at left...
2.	Adjuvant Chemotherapy 01/01/1995 - "PURPOSE: In a previous randomized trial, the addition of adjuvant chemotherapy to postoperative radiotherapy proved beneficial in the treatment of childhood high-grade astrocytomas. " 02/01/2008 - "Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy." 01/15/2001 - "PURPOSE: Meta-analyses of the published literature suggest a survival benefit to adjuvant chemotherapy for high-grade astrocytoma, which individual small trials have been unable to demonstrate reliably. " 01/01/2007 - "The first patient was a 16-month-old girl who presented with a grade III intramedullary astrocytoma that rapidly progressed after surgery and adjuvant chemotherapy. " 11/20/2006 - "Anaplastic astrocytomas should be treated with postoperative radiation therapy with or without adjuvant chemotherapy. " Order ALL the reference details at left...
3.	Combination Drug Therapy (Combination Chemotherapy) 01/01/2008 - "Prospective single-arm study of 72 Gy hyperfractionated radiation therapy and combination chemotherapy for anaplastic astrocytomas." 12/01/2000 - "This result suggests that combination chemotherapy may offer treatment modalities for low grade astrocytoma." 04/01/1997 - "We studied the toxicity and efficacy of adding in sequence 4 resistance modulators to combination chemotherapy and radiotherapy in the treatment of glioblastoma multiforme and poor prognosis anaplastic astrocytomas. " 02/17/1983 - "Thirty-nine patients with malignant gliomas (36 glioblastomas, 3 astrocytomas grade III; age median 52.5) were treated after surgery by combination chemotherapy followed by irradiation. " 10/01/1987 - "Nineteen patients with biopsy-proven high-grade astrocytomas received as initial treatment whole-brain radiation and combination chemotherapy with 5-fluorouracil (5-FU), 1,000 mg/m2/24 h as a continuous infusion for 96 h, and bolus cisdiamminedichloroplatinum II (CDDP), 100 mg/m2. " Order ALL the reference details at left...
4.	Brachytherapy 12/01/1994 - "PURPOSE: To assess the efficacy of interstitial brachytherapy in the treatment of patients with recurrent malignant astrocytoma. " 07/15/1998 - "PURPOSE: A randomized study was undertaken to assess the role of brachytherapy as a boost to external beam radiation therapy in the initial management of patients with malignant astrocytomas. " 07/15/1998 - "Randomized study of brachytherapy in the initial management of patients with malignant astrocytoma." 04/01/2002 - "Interestingly, we observed the slow transformation of a solid, primarily inoperable anaplastic astrocytoma into a resectable multi-cystic lesion 2 years after radiopeptide brachytherapy. " 12/01/1994 - "CONCLUSION: Brachytherapy confers modest but meaningful prolongation of survival in selected patients with recurrent malignant astrocytoma, but complications are significant, reoperation frequently required, and recurrence outside the treatment volume common." Order ALL the reference details at left...
5.	Ketogenic Diet 01/01/2008 - "Dietary restriction of the high fat/low carbohydrate ketogenic diet (KD-R) reduces glycolysis and is effective in managing experimental mouse and human astrocytomas. " 01/01/2008 - "The results suggest that management of malignant astrocytoma with restricted ketogenic diets could be enhanced when combined with drugs that inhibit glycolysis." 01/01/2007 - "This study evaluated the efficacy of KetoCal, a new nutritionally balanced high fat/low carbohydrate ketogenic diet for children with epilepsy, on the growth and vascularity of a malignant mouse astrocytoma (CT-2A) and a human malignant glioma (U87-MG). " 10/21/2005 - "The approach focuses more on the genomic flexibility of normal cells than on the genomic defects of tumor cells and is supported from recent studies in orthotopic mouse brain tumor models and in human pediatric astrocytoma treated with dietary energy restriction and the ketogenic diet." 01/01/2008 - "Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet." Order ALL the reference details at left...