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Heterologous Transplantation (Xenotransplantation)

Transplantation between animals of different species.
Also Known As:
Xenotransplantation; Transplantation, Heterologous; Heterograft Transplantation; Heterografting; Xenograft Transplantation; Xenografting; Transplantation, Heterograft; Transplantation, Xenograft
Networked: 1981 relevant articles (68 outcomes, 271 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1. Cooper, David K C: 49 articles (10/2022 - 05/2002)
2. Hara, Hidetaka: 19 articles (10/2022 - 08/2012)
3. Denner, Joachim: 16 articles (01/2021 - 01/2008)
4. Iwase, Hayato: 15 articles (01/2021 - 11/2011)
5. Fishman, Jay A: 14 articles (01/2020 - 05/2002)
6. Ayares, David: 13 articles (10/2022 - 11/2009)
7. Tector, A Joseph: 13 articles (01/2017 - 02/2002)
8. Pierson, Richard N: 12 articles (01/2022 - 07/2009)
9. Sachs, David H: 11 articles (11/2021 - 05/2002)
10. Ekser, Burcin: 10 articles (01/2022 - 06/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Infections
12/30/1998 - ""Xenosis," infection in xenotransplantation, may be increased beyond that of allotransplantation because: (1) the xenograft may serve as a permissive focus of infection for donor-derived organisms; (2) these organisms may be unknown or xenotropic; (3) microbiologic assays may be unavailable; (4) clinical syndromes due to such novel pathogens may not be recognized; (5) the necessary level of immune suppression may be greater than for allotransplantation; (6) donor-derived organisms may acquire new (e.g., genetic) characteristics in the human host; (7) the presence of immune suppression and the high, intrinsic rate of infection may mask the presence of xenosis; and (8) MHC-incompatibility may reduce the efficacy of the immune response within the xenograft. "
01/01/2000 - "Adoptive transfer of immunity with such therapies as bone marrow or cytotoxic T lymphocyte transplants or xenotransplantation of an organ from a donor, which is not susceptible to infection by HBV may be effective in preventing or treating recurrent HBV posttransplantation. "
01/01/2001 - "Unfortunately, polymerase chain reaction (PCR)-based analysis of potential PERV infections in nonhuman-primate whole-organ xenotransplantation models is hampered by false positive results due to chimeric porcine cells. "
05/29/2020 - "Further, xenotransplantation of human hepatocytes into mice allows for the direct study of HCV infection in human liver tissue in a small animal model. "
12/01/2018 - "We cannot appreciate the full risk of infections after xenotransplantation in absence of clinical trials. "
3. Type 1 Diabetes Mellitus (Autoimmune Diabetes)
4. Neoplasm Metastasis (Metastasis)
5. Psoriasis (Pustulosis Palmaris et Plantaris)

Related Drugs and Biologics

1. Insulin (Novolin)
2. Leflunomide (Arava)
3. cucurbitacin I
4. Antibodies
5. Complement System Proteins (Complement)
6. Small Interfering RNA (siRNA)
7. DNA (Deoxyribonucleic Acid)
8. Immunosuppressive Agents (Immunosuppressants)
9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10. Methylcholanthrene

Related Therapies and Procedures

1. Therapeutics
2. Transplantation
3. Drug Therapy (Chemotherapy)
4. Injections
5. Operative Surgical Procedures