Abstract | BACKGROUND: METHODS AND RESULTS:
Hemostatic risk factors were measured in 1878 individuals (1003 women and 875 men) participating in cycle 5 of the Framingham Offspring Study. The subjects were divided into five groups on the basis of LDL cholesterol level. Subjects with hypobetalipoproteinemia ( LDL cholesterol < 70 mg/dL) had the lowest levels of fibrinogen, plasminogen activator inhibitor-1 antigen, and tissue plasminogen activator antigen. As LDL cholesterol increased, there was a significant increase in the levels of the hemostatic risk factors, with the exception of von Willebrand factor antigen. Adjustment with multivariate regression analyses for the covariates age, sex, body mass index, diabetes mellitus, smoking, alcohol intake, triglyceride level, and use of antihypertensive medication did not materially alter the results. CONCLUSIONS:
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Authors | F K Welty, M A Mittleman, P W Wilson, P A Sutherland, T H Matheney, I Lipinska, J E Muller, D Levy, G H Tofler |
Journal | Circulation
(Circulation)
Vol. 95
Issue 4
Pg. 825-30
(Feb 18 1997)
ISSN: 0009-7322 [Print] United States |
PMID | 9054738
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Apolipoproteins B
- Cholesterol, HDL
- Cholesterol, LDL
- Plasminogen Activator Inhibitor 1
- Triglycerides
- von Willebrand Factor
- Factor VII
- Fibrinogen
- Tissue Plasminogen Activator
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Topics |
- Apolipoproteins B
(blood)
- Cardiovascular Diseases
(epidemiology)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Factor VII
(analysis)
- Female
- Fibrinogen
(analysis)
- Humans
- Hypobetalipoproteinemias
- Longitudinal Studies
- Male
- Middle Aged
- Plasminogen Activator Inhibitor 1
(blood)
- Prospective Studies
- Risk Factors
- Smoking
- Tissue Plasminogen Activator
(blood)
- Triglycerides
(blood)
- von Willebrand Factor
(analysis)
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