Efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) on an ARC/AIDS rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus.

Abstract

The efficacy of 6-chloro-2',3'-dideoxyguanosine (6-Cl-ddG) was investigated in vivo by using a male ARC/AIDS rhesus macaque infected with simian immunodeficiency virus (SIVmac251/32H). He was administered subcutaneously 6-Cl-ddG (50 mg/kg B.W.) every 8 hr for 14 days when he showed clinical features of recurrent weight loss, severe diarrhea and neuropathy. The number of CD4+, CD8+ cells and total T cells increased rapidly after administration of 6-Cl-ddG and a high level was maintained for 2 months, but the B cell count decreased during the treatment. The antibody titer to SIV did not change significantly during or after the treatment, but the virus load in the plasma measured by RT-PCR dropped to one-third at the start of the 6-Cl-ddG treatment. Within 3 days after the start of 6-Cl-ddG administration, he began to show recovery in clinical signs including weight increase, and disappearance of diarrhea and neuropathy. These findings suggested that 6-Cl-ddG was effective at the stage of ARC/AIDS in a rhesus monkey infected with SIV.

• Authors: Y Fujii, R Mukai, Y Murayama, H Akari, M Machida, K Mori, M Takasaka, K Murakami, Y Yoshikawa
• Journal: Experimental animals (Exp Anim) Vol. 46 Issue 1 Pg. 83-7 (Jan 1997) ISSN: 1341-1357 [Print] Japan
• PMID: 9027477 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 6-chloro-2',3'-dideoxyguanosine
• Antiviral Agents
• Dideoxynucleosides

Topics

• Animals
• Antiviral Agents (therapeutic use)
• CD4 Lymphocyte Count
• CD8-Positive T-Lymphocytes
• Dideoxynucleosides (therapeutic use)
• Lymphocyte Count
• Macaca mulatta
• Male
• Simian Acquired Immunodeficiency Syndrome (drug therapy)
• Simian Immunodeficiency Virus