Abstract |
The beneficial effect of long-term treatment with an angiotensin-converting enzyme ( ACE) inhibitor on urinary microalbumin excretion (UAE) and renal function was investigated in a 4 year, randomized prospective study in normotensive patients with non- insulin-dependent ( Type 2) diabetes mellitus. Sixty-two normotensive patients with Type 2 diabetes mellitus and microalbuminuria but normal renal function were randomized to receive either enalapril 5 mg day-1 or no treatment. In the enalapril-treated patients, UAE was reduced from 115.4 +/- 80.1 to 95.6 +/- 61.7 mg 24 h-1 after 12 months (p < 0.05) and to 75.3 +/- 44.8 mg 24 h-1 after 48 months (p < 0.001). In the untreated group, UAE increased slowly from 93.9 +/- 69.9 to 150.0 +/- 144.5 mg 24 h-1 after 48 months. No changes in creatinine clearance, blood pressure or HbA1C were seen in either group during the 4-year period. In normotensive Type 2 diabetic patients with early stage of diabetic microalbuminuria. This effect is long-lasting and probably independent of the antihypertensive action of the drug.
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Authors | T Sano, N Hotta, T Kawamura, H Matsumae, S Chaya, H Sasaki, M Nakayama, T Hara, S Matsuo, N Sakamoto |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 13
Issue 2
Pg. 120-4
(Feb 1996)
ISSN: 0742-3071 [Print] England |
PMID | 8641115
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Enalapril
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Topics |
- Aged
- Albuminuria
(drug therapy, etiology)
- Analysis of Variance
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage)
- Blood Pressure
(drug effects)
- Diabetes Mellitus, Type 2
(complications, physiopathology)
- Diabetic Nephropathies
(drug therapy, urine)
- Drug Administration Schedule
- Enalapril
(administration & dosage)
- Follow-Up Studies
- Humans
- Middle Aged
- Prospective Studies
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