Abstract | BACKGROUND: METHODS: Serum and 24-hour urine samples were collected and assayed serially by high-performance liquid chromatography every 1 to 4 months in 28 patients with primary or recurrent melanomas, for up to 48 months. RESULTS: Serum concentration and urinary excretion of 5-S-CD and 6H5MI2C in patients with melanoma without metastases were close to those obtained from normal subjects. Metastases developed in 9 of the 28 patients. In seven of these nine patients, serum or urinary 5-S-CD values were elevated before or at the time of clinical detection of visceral metastases. However, serum 5-S-CD was elevated significantly earlier and reflected melanoma progression better than the physical examination and/or laboratory tests, such as scintigraphy and echography. Serum 6H5MI2C values exceeded the normal range shortly before death in three patients, and urinary 6H5MI2C did not increase at any stage in most patients, therefore these metabolites did not reflect progression of disease. CONCLUSIONS:
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Authors | T Horikoshi, S Ito, K Wakamatsu, H Onodera, H Eguchi |
Journal | Cancer
(Cancer)
Vol. 73
Issue 3
Pg. 629-36
(Feb 01 1994)
ISSN: 0008-543X [Print] United States |
PMID | 8299084
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Indoles
- Cysteinyldopa
- 5-hydroxy-6-methoxy-2-indolylcarboxylic acid
- 5,6-dihydroxy-2-indolylcarboxylic acid
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Chromatography, High Pressure Liquid
- Cysteinyldopa
(analysis, blood)
- Female
- Humans
- Indoles
(analysis)
- Male
- Melanoma
(diagnosis, pathology)
- Middle Aged
- Neoplasm Metastasis
- Skin Neoplasms
(diagnosis, pathology)
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