[Problems of the clinical polymorphism of hereditary extrapyramidal disorders].

Abstract

The authors analyse the polymorphism of certain hereditary extrapyramidal system diseases and call attention to their intrafamilial and interfamilial characteristics. Various diseases are described: 5 forms of hepatolenticular degeneration, 2 forms of torsion dystonia, 3 forms of idiopathic tremor, 3 forms of Huntington's chorea. Clinical peculiarities, peculiarities of the course of the disease, and biochemical changes in these diseases are discussed. In the forms associated with rigidity or with hyperkinesis in the same disease (torsion dystonia, Huntington's chorea) abnormalities of various directions were discovered in the metabolism of neurotransmitters and amino acids, which make possible application of differentiated pathogenetic therapy.

• Authors: E D Markowa, J A Iwanowa-Smolenskaja, L M Alijewa, A Członkowska
• Journal: Neurologia i neurochirurgia polska (Neurol Neurochir Pol) 1981 Jul-Aug Vol. 15 Issue 4 Pg. 373-6 ISSN: 0028-3843 [Print] Poland
• Vernacular Title: Zagadnienia polimorfizmu klinicznego dziedzicznych chorób pozapiramidowych.
• PMID: 7329504 (Publication Type: English Abstract, Journal Article)

Chemical References

• Levodopa

Topics

• Basal Ganglia Diseases (drug therapy, etiology, genetics)
• Genotype
• Humans
• Levodopa (therapeutic use)
• Polymorphism, Genetic