Dystonia Musculorum Deformans (Torsion Dystonia)

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152 relevant articles (9 outcomes, 10 trials/studies) found for this Disease

Description: A condition characterized by focal DYSTONIA that progresses to involuntary spasmodic contractions of the muscles of the legs, trunk, arms, and face. The hands are often spared, however, sustained axial and limb contractions may lead to a state where the body is grossly contorted. Onset is usually in the first or second decade. Familial patterns of inheritance, primarily autosomal dominant with incomplete penetrance, have been identified. (Adams et al., Principles of Neurology, 6th ed, p1078)

Also Known As:

Torsion Dystonia; Dystonia Deformans Musculorum; Dystonia Deformans Progressiva; Torsion Disease of Childhood; Dystonia, Idiopathic Torsion; Dystonias, Idiopathic Torsion; Dystonias, Torsion; Idiopathic Torsion Dystonias; Oppenheim Ziehen Disease; Spasm, Progressive Torsion; Torsion Disease, Childhood; Torsion Dystonia, Idiopathic; Torsion Spasm, Progressive; Childhood Torsion Disease; Idiopathic Torsion Dystonia; Oppenheim-Ziehen Disease; Progressive Torsion Spasm

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3422

Neurodegenerative Diseases: 7370

Nervous System Heredodegenerative Disorders: 24

Dystonia Musculorum Deformans: 152

Central Nervous System Diseases: 931

Movement Disorders: 1473

Dystonic Disorders: 342

Dystonia Musculorum Deformans: 152

Brain Diseases: 1121

Basal Ganglia Diseases: 181

Dystonia Musculorum Deformans: 152

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 422

Inborn Genetic Diseases: 549

Nervous System Heredodegenerative Disorders: 24

Dystonia Musculorum Deformans: 152

Related Diseases

1.	Dystonia (Limb Dystonia)
2.	Syndrome
3.	Parkinson Disease (Parkinson's Disease)
4.	Dystonic Disorders (Writer's Cramp)
5.	Dyskinesias (Dyskinesia)

Experts

1.	Bressman, S B: 2 articles (08/2007 - 10/2004)
2.	Alterman, R L: 2 articles (08/2007 - 01/2007)
3.	Olufolabi, A J: 2 articles (09/2006 - 05/2006)
4.	Wee, M Y K: 2 articles (09/2006 - 05/2006)
5.	Vesper, J: 2 articles (01/2002 - 01/2002)
6.	Klostermann, F: 2 articles (01/2002 - 01/2002)
7.	Tagliati, Michele: 1 article (09/2007)
8.	Alterman, Ron L: 1 article (09/2007)
9.	Tagliati, M: 1 article (08/2007)
10.	Weisz, D: 1 article (08/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dystonia Musculorum Deformans:

1.	Levodopa (L Dopa)FDA LinkGeneric 01/01/1975 - "For patients with torsion dystonia, where the so-called myostatic component preponderates, cautious application of L-DOPA seems to be justified and further clinical studies are suggested." 10/01/2004 - "Pathophysiological mechanisms of the muscular tone was studied clinicoelectrophysiologically (the method of stimulating electromyography with evoked H-reflex) in 130 healthy subjects and 63 patients with dystonia musculorum deformans (23 patients of the latter were examined before and after intake of a therapeutic dose of L-DOPA)" 01/01/1988 - "Long-term treatment with levodopa in a family with autosomal dominant torsion dystonia." 01/01/1985 - "The results indicate the efficiency of L-DOPA in the treatment of dystonia musculorum deformans and dystonic hyperkineses against the residual organic background" 01/01/1985 - "Nineteen children with dystonia musculorum deformans and dystonic hyperkineses were treated by L-DOPA" Order ALL the reference details at left...
2.	Trihexyphenidyl (Artane)FDA LinkGeneric 02/01/1986 - "High-dosage trihexyphenidyl therapy is effective in the management of torsion dystonia." 02/01/1986 - "Torsion dystonia: a double-blind, prospective trial of high-dosage trihexyphenidyl." 02/01/1986 - "We studied trihexyphenidyl in the treatment of torsion dystonia in a prospective, double-blind crossover protocol" 07/01/1985 - "Serum trihexyphenidyl levels in the treatment of torsion dystonia." 07/01/1952 - "Dystonia musculorum deformans in siblings; treated with artane (trihexyphenidyl)." Order ALL the reference details at left...
3.	Neurotransmitter Agents (Neurotransmitter)IBA 08/07/1986 - "Brain neurotransmitters in dystonia musculorum deformans." 01/01/1988 - "Biochemical evidence for brain neurotransmitter changes in idiopathic torsion dystonia (dystonia musculorum deformans)." 07/01/1981 - "In the forms associated with rigidity or with hyperkinesis in the same disease (torsion dystonia, Huntington's chorea) abnormalities of various directions were discovered in the metabolism of neurotransmitters and amino acids, which make possible application of differentiated pathogenetic therapy." 07/01/1981 - "The best results in akinetic-rigidity syndromes (Parkinson's disease, rigid froms of torsion dystonia, Hallevorden-Spatz disease) were obtained with L-DOPA (including Sinemet, Nacom, Madopar) and in many patients these preparations were given in combination with other drugs (cholinolytic agents, Midantan) which contributed to compensation of the disturbed equilibrium of neurotransmitter systems and reduction of side effects" Order ALL the reference details at left...
4.	Baclofen FDA LinkGeneric 05/01/1996 - "To our knowledge, this is the first reported case of continuous intrathecal baclofen for hereditary torsion dystonia" 05/01/1996 - "Intrathecal baclofen for severe torsion dystonia in a child." 01/16/2000 - "CONCLUSION: We propose continuous baclofen intrathecal infusion pump for patients with severe torsion dystonia that not response to ordinal treatment." 05/01/1996 - "This case suggests that a continuous intrathecal infusion of baclofen may facilitate remission of intractable torsion dystonia, and provides a basis for further investigation of the treatment of intractable childhood dystonia." 05/01/1996 - "The successful use of intrathecal baclofen, a structural analogue of gamma-aminobutyric acid, is described in the treatment of a 9-year-old boy with intractable torsion dystonia, not responding to conservative treatment" Order ALL the reference details at left...
5.	phenothiazineIBA 01/01/1978 - "Torsion dystonia: a case with delayed remission following thalamotomy and phenothiazine therapy." 07/01/1981 - "In the hyperkinetic syndromes (Huntington's chorea, idiopathic tremor, myoclonic epilepsy, hyperkinetic torsion dystonia) preparations of phenothiazine, butyrophenone and new drugs active on the GABAergic system (Baclophen, Lyoresal, Pantogam) and diazepine (Clonazepam) were used" Order ALL the reference details at left...
6.	Sinemet (Nakom)FDA LinkGeneric 01/01/1992 - "As many as 8 patients aged 8-19 years suffering from infantile cerebral paralysis (ICP) with torsion dystonia, akinetic, rigid, spastic and hypotonically atactic syndromes were examined for the maximum amplitude of EMG activity of the musculus tibialis anterior in voluntary rear flexion of the foot and in Strümpell's tibial synkinesia before treatment and after intake of small doses of L-DOPA (nakom, 62 mg/day)" 07/01/1981 - "The best results in akinetic-rigidity syndromes (Parkinson's disease, rigid froms of torsion dystonia, Hallevorden-Spatz disease) were obtained with L-DOPA (including Sinemet, Nacom, Madopar) and in many patients these preparations were given in combination with other drugs (cholinolytic agents, Midantan) which contributed to compensation of the disturbed equilibrium of neurotransmitter systems and reduction of side effects" Order ALL the reference details at left...
7.	Risperidone (Risperdal Consta)FDA Link 04/01/2000 - "We studied the efficacy of risperidone in the treatment of idiopathic and symptomatic dystonias in seven patients using the Fahn and Marsden rating scale for torsion dystonia before and after four weeks of treatment (2-6 mg/day)" Order ALL the reference details at left...
8.	Amantadine (Aman)FDA LinkGeneric 07/01/1981 - "The best results in akinetic-rigidity syndromes (Parkinson's disease, rigid froms of torsion dystonia, Hallevorden-Spatz disease) were obtained with L-DOPA (including Sinemet, Nacom, Madopar) and in many patients these preparations were given in combination with other drugs (cholinolytic agents, Midantan) which contributed to compensation of the disturbed equilibrium of neurotransmitter systems and reduction of side effects" Order ALL the reference details at left...
9.	madoparIBA 07/01/1981 - "The best results in akinetic-rigidity syndromes (Parkinson's disease, rigid froms of torsion dystonia, Hallevorden-Spatz disease) were obtained with L-DOPA (including Sinemet, Nacom, Madopar) and in many patients these preparations were given in combination with other drugs (cholinolytic agents, Midantan) which contributed to compensation of the disturbed equilibrium of neurotransmitter systems and reduction of side effects" Order ALL the reference details at left...
10.	Dopamine beta-HydroxylaseIBA 10/01/1990 - "Since a postmortem biochemical study and a genetic linkage study of idiopathic torsion dystonia suggested possible involvement of dopamine beta-hydroxylase (DBH), we determined CSF DBH activities of Jewish and non-Jewish patients with childhood-onset idiopathic torsion dystonia and found no differences from a control population." 01/01/1980 - "A familial study of 13 Ashkenasy Jewish patients suffering from torsion dystonia (TD) of various origin, was carried out using clinical observation and determination of serum dopamine-beta-hydroxylase (DBH) activity" 07/01/1974 - "A familial study in serum dopamine-beta-hydroxylase levels in torsion dystonia." 09/25/2001 - "The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia" 10/01/1990 - "Dopamine beta-hydroxylase activity in cerebrospinal fluid of idiopathic torsion dystonia." Order ALL the reference details at left...

Therapies and Procedures

1.	Deep Brain Stimulation 09/01/2007 - "INTRODUCTION: Deep brain stimulation (DBS) at the internal globus pallidus (GPi) is an effective treatment for some patients with medically refractory torsion dystonia" 01/01/2007 - "Deep brain stimulation (DBS) at the globus pallidus pars internus (GPi) is an effective treatment for some patients with medically refractory torsion dystonia" 09/01/2007 - "Deep brain stimulation for torsion dystonia in children." 08/14/2007 - "Sixty hertz pallidal deep brain stimulation for primary torsion dystonia." 01/01/2007 - "Deep brain stimulation for torsion dystonia." Order ALL the reference details at left...
2.	Overlay Denture 05/01/2001 - "The present paper reports on a patient with idiopathic torsion dystonia who was treated with a mandibular overdenture supported by endosteal implants, which enabled the establishment of a stable occlusion and improved the dynamics of the masticatory muscles for chewing." Order ALL the reference details at left...
3.	Pallidotomy 10/01/1999 - "This report describes the successful treatment of dystonia musculorum deformans with bilateral stereotactic pallidotomy in a 14-year-old girl in whom the dystonia was diagnosed when she was 7 years old" 05/01/1997 - "Ventrolateral (VL)-thalamotomy and posteroventral pallidotomy were carried out in 37 patients with idiopathic dystonia, including 23 with dystonia musculorum deformans, 12 with Meige syndrome and 2 with focal dystonia" Order ALL the reference details at left...
4.	Infusion Pumps (Infusion Pump) 01/01/2008 - "We report the case of a 59-year-old man with chronic spasticity and torsion dystonia who developed meningitis due to Staphylococcus epidermidis due to contamination of the intrathecal, infusion pump reservoir during refilling" 01/16/2000 - "CONCLUSION: We propose continuous baclofen intrathecal infusion pump for patients with severe torsion dystonia that not response to ordinal treatment." Order ALL the reference details at left...
5.	Cesarean Section (Caesarean Section) 09/01/2006 - "Caesarean section in a patient with torsion dystonia." 05/01/2006 - "We present a case of torsion dystonia in a 35-yr-old primigravida who presented for a Caesarean section under general anaesthesia" 05/01/2006 - "Caesarean section in a patient with torsion dystonia." Order ALL the reference details at left...

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