[Safety, antigenic activity, and epidemiologic effectiveness of live mumps vaccine from strain Leningrad-3. I. Reactogenic, allergenic and mutagenic properties of the vaccine and its effect on the body's resistance to intercurrent diseases].

Abstract

The influence of 3 batches of live parotitis vaccine from strain L-3 on the organism of 2,536 vaccinated children of preschool and junior school age was studied. The injection of this preparation was shown to induce weak and moderate systemic reactions on the average in 0.8% of the children and local hyperemia of the skin in 7.8% of the children during the first 2-4 days. No severe reactions and complications were observed. Parotitis vaccine induced the weak specific and nonspecific allergic transformation of the organism, did not significantly increase the frequency of aberrant metaphases in the lymphocyte culture, did not essentially influence the frequency of intercurrent diseases at the proximate (21 days) and remote (1 year) periods after immunization, did not suppress the intensity of postvaccinal immunity to pertussis, diphtheria and tetanus. Though various batches of the vaccine showed no sharp differences in their influence on the organism, nevertheless postvaccinal reactions were found to be more frequent, and intercurrent diseases occurred more rarely in the children immunized with the batch containing 20,000 HADU50.

• Authors: N P Grazhdanov, V F Popov, A A Sokhin, L V Salmin, A K Frolov
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 1 Pg. 69-74 (Jan 1981) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Bezvrednost', antigennaia aktivnost' i épidemiologicheskaia éffektivnost' zhivoĭ parotitnoĭ vaktsiny iz shtamma Leningrad-3. Soobshchenie I. Reaktogennye, allergennye i mutagennye svoĭstva vaktsiny i ee vliianie na rezistentnost' organizma k interkurrentnym zabolevaniiam.
• PMID: 7234245 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Bacterial
• Mumps Vaccine
• Smallpox Vaccine

Topics

• Antibodies, Bacterial (analysis)
• Child
• Child, Preschool
• Chromosome Aberrations
• Fever (etiology)
• Humans
• Hypersensitivity (etiology)
• Lymphocytes (ultrastructure)
• Mumps (complications, prevention & control)
• Mumps Vaccine (adverse effects)
• Skin Diseases (etiology)
• Smallpox (complications, prevention & control)
• Smallpox Vaccine (adverse effects)
• Vaccination