Adrenergic beta receptors mediating submandibular salivary gland hypertrophy in the rat.

Abstract

Multiple injections of dobutamine, a selective adrenergic beta-1 receptor agonist, or isoproterenol, a nonselective beta receptor agonist, produced significant dose-dependent enlargement of the submandibular glands of male rats. The glandular enlargement induced by dobutamine or isoproterenol was characterized by significant increases in glandular protein and nucleic acid content and a marked increase in the RNA/DNA ratio. Metoprolol, a selective beta-1 receptor antagonist, significantly inhibited the glandular enlargement induced by dobutamine or isoproterenol and produced a parallel shift in the isoproterenol dose-response curve. Metoprolol also inhibited the increased protein and nucleic acid content induced by dobutamine or isoproterenol. Multiple injections of selective adrenergic beta-2 receptor agonists, terbutaline, fenoterol or salmefamole, failed to produce submandibular gland enlargement. These results indicate that adrenergic beta-1 receptors mediate submandibular gland hypertrophy in the rat.

• Authors: G M Brenner, R G Wulf
• Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther) Vol. 218 Issue 3 Pg. 608-12 (Sep 1981) ISSN: 0022-3565 [Print] United States
• PMID: 6115050 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Receptors, Adrenergic
• Receptors, Adrenergic, beta
• Metoprolol
• Isoproterenol

Topics

• Adrenergic beta-Agonists (pharmacology)
• Animals
• Cardiomegaly (chemically induced)
• Dose-Response Relationship, Drug
• Hypertrophy (chemically induced, physiopathology)
• Isoproterenol (pharmacology)
• Male
• Metoprolol (pharmacology)
• Rats
• Receptors, Adrenergic (physiology)
• Receptors, Adrenergic, beta (physiology)
• Submandibular Gland (drug effects, pathology)