Abstract | RATIONALE: OBJECTIVES: Compare the effects of LAT and fluoxetine on depression-like behaviors in mice exposed to CSDS. RESULT: The CSDS-induced decrease in protein expression of postsynaptic density (PSD95), brain derived neurotrophic factor ( BDNF), and glutamate receptor subunit-1 (GluA1) in the prefrontal cortex was restored by LAT. LAT showed robust anti-inflammatory activity and can lessen the increase in IL-6 and TNF-α caused by CSDS. CSDS altered the gut microbiota at the taxonomic level, resulting in significant changes in α- and β-diversity. LAT treatment reestablished the bacterial abundance and diversity and increased the production of butyric acid in the gut that was inhibited by CSDS. The levels of butyric acid were negatively correlated with the abundance of Bacteroidetes, and positively correlated with those of Proteobacteria and Firmicutes across all treatment groups. CONCLUSIONS: The current data suggest that, similar to fluoxetine, LAT show antidepressant-like effects in mice exposed to CSDS through the modulation of the gut-brain axis.
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Authors | Siming Wang, Qihan Cai, Lu Xu, Yanan Sun, Mengmeng Wang, Yu Wang, Lili Zhang, Keqing Li, Zhiyu Ni |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 240
Issue 8
Pg. 1775-1787
(Aug 2023)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 37400661
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s). |
Chemical References |
- Fluoxetine
- isoalantolactone
- Butyric Acid
- Antidepressive Agents
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Topics |
- Animals
- Mice
- Depression
(drug therapy, metabolism)
- Fluoxetine
(pharmacology)
- Social Defeat
- Brain-Gut Axis
- Butyric Acid
- Antidepressive Agents
(pharmacology, therapeutic use)
- Stress, Psychological
(drug therapy, metabolism)
- Mice, Inbred C57BL
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