Abstract | BACKGROUND: METHODS: Medline, Embase and Cochrane CENTRAL were searched for randomized controlled trials (RCTs) on tirzepatide's weight loss efficacy for these patients. A single arm meta-analysis of proportions estimated primary outcomes, ≥5%, ≥10%, and ≥15% weight loss, and adverse events (AEs); while meta-analysis of means estimated secondary outcomes. Comparative meta-analysis was conducted between tirzepatide and control arms where mean differences and odds ratios were estimated for continuous and dichotomous outcomes respectively. RESULTS: RCTs included in this study revealed that among 5800 patients, 78.22% (95% CI: 72.15% to 83.73%), 55.60% (95% CI: 46.54% to 64.47%), 32.28% (95% CI: 23.17% to 42.12%) achieved ≥5%, ≥10%, and ≥15% weight loss, respectively. Tirzepatide 5 mg demonstrated weight loss superiority relative to placebo (MD: -12.47 kg, 95% CI: -13.94 kg to -11.00 kg) and semaglutide (n = 1409, MD: -1.90 kg, 95% CI: -2.97 kg to -0.83 kg) with dose-dependent increase for 10 mg and 15 mg doses. The comparison between tirzepatide and semaglutide was examined in the SURPASS-2 trial that was included in this systematic review. For AEs, there was increase odds of experiencing gastrointestinal AEs with tirzepatide compared to placebo, but no significant difference with semaglutide. CONCLUSION:
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Authors | Bryan Tan, Xin-Hui Pan, Han Shi Jocelyn Chew, Rachel Sze Jen Goh, Chaoxing Lin, Vickram Vijay Anand, Ethan Cheng Zhe Lee, Kai En Chan, Gwyneth Kong, Christen En Ya Ong, Hui Charlotte Chung, Dan Yock Young, Mark Y Chan, Chin Meng Khoo, Anurag Mehta, Mark Dhinesh Muthiah, Mazen Noureddin, Cheng Han Ng, Nicholas W S Chew, Yip Han Chin |
Journal | International journal of obesity (2005)
(Int J Obes (Lond))
Vol. 47
Issue 8
Pg. 677-685
(08 2023)
ISSN: 1476-5497 [Electronic] England |
PMID | 37253796
(Publication Type: Meta-Analysis, Systematic Review, Journal Article, Review)
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Copyright | © 2023. The Author(s), under exclusive licence to Springer Nature Limited. |
Chemical References |
- tirzepatide
- Gastric Inhibitory Polypeptide
- Anti-Obesity Agents
- Hypoglycemic Agents
- Glucagon-Like Peptide-1 Receptor
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Topics |
- Humans
- Overweight
(drug therapy)
- Obesity
(drug therapy)
- Gastric Inhibitory Polypeptide
- Anti-Obesity Agents
(adverse effects)
- Weight Loss
- Diabetes Mellitus, Type 2
- Hypoglycemic Agents
- Glucagon-Like Peptide-1 Receptor
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