SOX2 function in cancers: Association with growth, invasion, stemness and therapy response.

Abstract

Cancer is a leading cause of death worldwide and around 10 million deaths in 2020 were related to cancer. There are a number of therapeutic modalities for cancer such as chemotherapy, radiotherapy and surgery. However, tumor cells have capacity of developing resistance to chemotherapy and radiotherapy. Genetic mutations participate in development and progression of cancer. The current review focuses on the role of SOX2 transcription factor in cancer. SOX2 has capacity of increasing growth and metastasis of cancer cells. It functions as double-edged sword and has ability of suppressing tumor progression. Increasing evidence reveals that SOX2 is involved in triggering resistance to chemotherapy and radiotherapy. SOX2 promotes stemness of tumor cells and increases the number of cancer stem cells. SOX2 overexpression occurs in the tumor cells and tissues to ensure their proliferation and metastasis. Silencing SOX2 using CRISPR or siRNA impairs progression of the cancer cells and reduces their survival rate. SOX2 demonstrates interactions with other factors such as miRNAs, lncRNAs, STAT3 and Wnt/β-catenin, among others to regulate progression of the tumor cells. SOX2 can be considered as a biomarker in cancer patients. SOX2 overexpression is associated with lymph node metastasis, low survival rate and poor prognosis of cancer patients.

• Authors: Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Maliheh Entezari, Seyed Reza Mirmazloomi, Aria Hassanpoor, Maryam Aboutalebi, Shamin Rezaei, Elahe Sadat Hejazi, Amirabbas Kakavand, Hajar Heidari, Shokooh Salimimoghadam, Afshin Taheriazam, Mehrdad Hashemi, Saeed Samarghandian
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 156 Pg. 113860 (Dec 2022) ISSN: 1950-6007 [Electronic] France
• PMID: 36272267 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022. Published by Elsevier Masson SAS.

Chemical References

• SOXB1 Transcription Factors
• RNA, Long Noncoding
• MicroRNAs
• SOX2 protein, human

Topics

• Humans
• SOXB1 Transcription Factors (genetics)
• Neoplasms (genetics, pathology)
• Neoplastic Stem Cells (metabolism)
• RNA, Long Noncoding
• MicroRNAs
• Cell Line, Tumor
• Gene Expression Regulation, Neoplastic