Airway inflammation in adolescents and elderly women: Chronic air pollution exposure and polygenic susceptibility.

Abstract

BACKGROUND AND AIM:

The fractional exhaled nitric oxide (FeNO) concentration in the exhaled breath is a biomarker for eosinophilic airway inflammation. We explored the interplay between chronic air pollution exposure and polygenic susceptibility to airway inflammation at different critical age stages.

METHODS:

Adolescents (15 yr) enrolled in the GINIplus/LISA birth cohorts (n = 2434) and 220 elderly women (75 yr on average) enrolled in the SALIA cohort with FeNO measurements available were investigated. Environmental main effects of the mean of ESCAPE land-use regression air pollutant concentrations within a time window of 15 years and main effects of the polygenic risk scores (PRS) using internal weights from elastic net regression of genome-wide derived single nucleotide polymorphisms were investigated. Furthermore, we examined gene-environment interaction (GxE) effects on natural log-transformed FeNO levels by adjusted linear regression models.

RESULTS:

While we observed no significant environmental and polygenic main effects on airway inflammation in either age group, we found robust harmful effects of chronic nitrogen dioxide (NO2) exposure in the GxE models for elderly women (16.2 % increase in FeNO, p-value = 0.027). Stratified analyses found GxE effects between the PRS and chronic NO2 exposure in never-smoker elderly women and in adolescents without any inflammatory respiratory conditions.

CONCLUSIONS:

FeNO measurement is a useful biomarker to detect higher risk of NO2-induced eosinophilic airway inflammation in the elderly. There was limited evidence for GxE effects on airway inflammation in adolescents or the elderly. Further GxE studies in subpopulations should be conducted to investigate the assumption that susceptibility to airway inflammation differs between age stages.

• Authors: Sara Kress, Anna Kilanowski, Claudia Wigmann, Qi Zhao, Tianyu Zhao, Michael J Abramson, Monika Gappa, Marie Standl, Klaus Unfried, Tamara Schikowski
• Journal: The Science of the total environment (Sci Total Environ) Vol. 841 Pg. 156655 (Oct 01 2022) ISSN: 1879-1026 [Electronic] Netherlands
• PMID: 35697214 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Air Pollutants
• Biomarkers
• Nitric Oxide
• Nitrogen Dioxide

Topics

• Adolescent
• Aged
• Air Pollutants (analysis)
• Air Pollution (analysis)
• Biomarkers (analysis)
• Environmental Exposure (analysis)
• Female
• Humans
• Inflammation (chemically induced)
• Nitric Oxide (analysis)
• Nitrogen Dioxide (analysis)