NIR light-triggered peroxynitrite anion production via direct lanthanide-triplet photosensitization for enhanced photodynamic therapy.

Abstract

Peroxynitrite anion (ONOO-), a product derived from reaction between reactive oxygen species (ROS) and nitric oxide (NO), is considered to be a more toxic reactive species than most ROS for cancer photodynamic therapy (PDT). To promote the PDT effect, a viable method is to develop rational strategies for efficient ONOO- generation at targeted tumor sites. Herein, a heterostructure nanocomposite containing ZnO-coated lanthanide nanoparticles (LnNPs) is reported for ONOO--based PDT. In this nanocomposite, Nd3+-doped LnNPs are employed to realize efficient NIR-light-triggered ROS generation by activating the triplet state of chlorin-e6 (Ce6) photosensitizers via a direct lanthanide-to-triplet sensitization mechanism. Meanwhile, ZnO in the composite catalyzes the decomposition of S-nitrosoglutathione (GSNO) to generate NO in the tumor microenvironment. The coupled system allows the combination of photo-induced ROS and NO to produce ONOO-, leading to drastically promoted cancer cell apoptosis and tumor growth inhibition. This study establishes a new apoptosis-inducing PDT agent, which is potentially active in drug resistant malignancies.

• Authors: Xi Xiao, Bingzhu Zheng, Qiang Zheng, Zijie Lu, Dong Cen, Xiujun Cai, Xiang Li, Renren Deng
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 10 Issue 23 Pg. 4501-4508 (06 15 2022) ISSN: 2050-7518 [Electronic] England
• PMID: 35615958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anions
• Lanthanoid Series Elements
• Reactive Oxygen Species
• Peroxynitrous Acid
• Zinc Oxide

Topics

• Anions (therapeutic use)
• Humans
• Lanthanoid Series Elements (pharmacology, therapeutic use)
• Metal Nanoparticles
• Neoplasms (drug therapy)
• Peroxynitrous Acid
• Photochemotherapy (methods)
• Reactive Oxygen Species
• Tumor Microenvironment
• Zinc Oxide