Abstract | OBJECTIVES: METHODS: Forty-seven SZ patients were randomly assigned to two groups: 10Hz rTMS or sham stimulation over DLPFC (applied once daily) for 20 consecutive treatments. Body weight was assessed at baseline, at the end of week 1, week 2, week 3 and week 4. Clinical symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of week 4. RESULTS: We found that compared with patients in the sham group, 10Hz rTMS treatment significantly reduced body weight in patients with chronic SZ after a period of 4 weeks of stimulation. Interestingly, further analysis found that from the first week (5 sessions) of treatment, there was a significant difference in body weight between active and sham groups after controlling for baseline weight. However, active rTMS treatment did not improve the psychotic symptoms compared to sham stimulation. CONCLUSION: Our results suggest that add-on HF rTMS could be an effective therapeutic strategy for body weight control in patients with chronic SZ.
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Authors | Xiuru Su, Xuan Wang, Xiuling Pan, Xuan Zhang, Xinyan Lu, Long Zhao, Yingnan Chen, Yujie Shang, Lin Zhu, Shulan Lu, Xiaolin Zhu, Fengchun Wu, Meihong Xiu |
Journal | Current neuropharmacology
(Curr Neuropharmacol)
Vol. 21
Issue 2
Pg. 417-423
( 2023)
ISSN: 1875-6190 [Electronic] United Arab Emirates |
PMID | 35611778
(Publication Type: Randomized Controlled Trial, Journal Article)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Topics |
- Humans
- Schizophrenia
(diagnosis)
- Transcranial Magnetic Stimulation
(methods)
- Treatment Outcome
- Prefrontal Cortex
- Weight Loss
(physiology)
- Body Weight
(physiology)
- Double-Blind Method
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