Longitudinal measures of phthalate exposure and asthma exacerbation in a rural agricultural cohort of Latino children in Yakima Valley, Washington.

Abstract

Phthalates are a class of widely used synthetic chemicals found in commonly used materials and products. Epidemiological studies suggest phthalate exposure is associated with asthma outcomes, though most studies have not investigated phthalates as triggers of exacerbations in children diagnosed with asthma. This study used data from the Home Air in Agriculture Pediatric Intervention Trial (HAPI) to examine relationships between phthalate exposure and outcomes related to childhood asthma exacerbation. We used measures of phthalate metabolites and respiratory health measures including fractional exhaled nitric oxide (FENO), the Asthma Control Test (ACT), caregiver report of symptoms, and urinary leukotriene E4 (uLTE4) to estimate longitudinal associations using mixed effects models, adjusted for covariates. For 100% (i.e., doubling) increases in mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-2-ethylhexyl phthalate (MEHP), and mono-ethyl phthalate (MEP), concentrations of FENO increased by 8.7% (95% CI: 0.7-17.3), 7.2% (95% CI: 0.0-14.9), and 6.4% (95% CI: 0.0-13.3), respectively. All phthalate metabolites demonstrated associations with uLTE4, effect sizes ranging from an 8.7% increase in uLTE4 (95% CI: 4.3-12.5) for a 100% increase in MEHP to an 18.1% increase in uLTE4 (95% CI: 13.3-23.1) for a 100% increase in MNBP. In models of caregiver report of symptoms, no phthalate metabolites were significantly associated in primary models. No phthalate metabolites were associated with standardized ACT score. Our results suggest urinary phthalate metabolites are significant predictors of inflammatory biomarkers related to asthma exacerbation in children but not child and caregiver report of airway symptomatology.

• Authors: Ryan S Babadi, Anne M Riederer, Paul D Sampson, Sheela Sathyanarayana, Terrance J Kavanagh, Jennifer E Krenz, Syam S Andra, Seunghee Kim-Schulze, Karen L Jansen, Elizabeth Torres, Adriana Perez, Lisa R Younglove, Maria I Tchong-French, Catherine J Karr
• Journal: International journal of hygiene and environmental health (Int J Hyg Environ Health) Vol. 243 Pg. 113954 (06 2022) ISSN: 1618-131X [Electronic] Germany
• PMID: 35588565 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2022. Published by Elsevier GmbH.

Chemical References

• Environmental Pollutants
• Phthalic Acids
• phthalic acid

Topics

• Agriculture
• Asthma (epidemiology)
• Child
• Environmental Exposure
• Environmental Pollutants (urine)
• Hispanic or Latino
• Humans
• Phthalic Acids (urine)
• Washington