Polyphenolic Extracts of Coffee Cherry Husks Alleviated Colitis-Induced Neural Inflammation via NF-κB Signaling Regulation and Gut Microbiota Modification.

Abstract

Coffee cherry husks, the main byproduct of coffee production, contain an abundance of polyphenols. In this study, dextran sodium sulfate (DSS)-induced colitis mice were used to study the protective effects of polyphenolic extracts of coffee cherry husks (CCHP) on inflammation. The results indicated that CCHP administration alleviated the histological changes of DSS-induced colitis in mice and downregulated the mRNA level of TNF-α, IL-1β, IL-6 and Cox-2. Interestingly, CCHP inhibited the activation of microglia and suppressed neural inflammation in the brain. The TLR4/Myd88/NF-κB signaling pathway was examined and found to be inhibited by CCHP. Furthermore, a determination of the gut microbiota showed that an alteration of microbiota induced by DSS was restored by CCHP, including the decrease of the relative abundance of Proteobacteria and the increase of Bacteroidota. In conclusion, our results revealed the great potential of CCHP to alleviate brain inflammation in colitis mice by inhibiting the NF-κB signaling pathway and regulating gut microbiota.

• Authors: Sen Li, Yu Chen, Yu Zhang, Hongyan Lv, Lei Luo, Shuo Wang, Xiao Guan
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 70 Issue 21 Pg. 6467-6477 (Jun 01 2022) ISSN: 1520-5118 [Electronic] United States
• PMID: 35588304 (Publication Type: Journal Article)

Chemical References

• Coffee
• NF-kappa B
• Plant Extracts
• Dextran Sulfate

Topics

• Animals
• Coffee (metabolism)
• Colitis (chemically induced, drug therapy, genetics)
• Colon (metabolism)
• Dextran Sulfate (metabolism)
• Disease Models, Animal
• Gastrointestinal Microbiome
• Inflammation (metabolism)
• Mice
• Mice, Inbred C57BL
• NF-kappa B (genetics, metabolism)
• Plant Extracts (pharmacology)
• Signal Transduction