Abstract | BACKGROUND: OBJECTIVE: RESULTS: We found that PZ-DHA increased the activity of AMP-activated protein kinase (AMPK) and improved glucose uptake and mitochondrial function in an AMPK-dependent manner in untreated C2C12 myotubes. PZ-DHA treatment of the myotubes reversed PA-induced insulin resistance; this was indicated by increases in glucose uptake and the expression of membrane glucose transporter 4 (Glut4) and phosphorylated Akt. Moreover, PZ-DHA treatment reversed PA-induced inflammation and oxidative stress. These effects of PZ-DHA were mediated by AMPK. Furthermore, the increase in AMPK activity, improvement in insulin resistance, and decrease in inflammatory and oxidative responses after PZ-DHA treatment diminished upon co-treatment with a liver kinase B1 (LKB1) inhibitor, suggesting that PZ-DHA improved AMPK activity by regulating its upstream kinase, LKB1. CONCLUSION:
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Authors | Jingqing Chen, Zhenlong Wu, Jin Wang, Xuemeng Si, Rui Zhang, Tianqi Sun, Qiaoyan Dong, Wenqing Wu, Yefeng Qiu |
Journal | Current pharmaceutical design
(Curr Pharm Des)
Vol. 28
Issue 22
Pg. 1854-1862
( 2022)
ISSN: 1873-4286 [Electronic] United Arab Emirates |
PMID | 35585811
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Esters
- Insulin
- Docosahexaenoic Acids
- Palmitic Acid
- Phlorhizin
- AMP-Activated Protein Kinases
- Glucose
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Topics |
- AMP-Activated Protein Kinases
- Cell Line
- Diabetes Mellitus, Type 2
- Docosahexaenoic Acids
- Esters
- Glucose
- Humans
- Inflammation
- Insulin
- Insulin Resistance
- Muscle Fibers, Skeletal
- Palmitic Acid
- Phlorhizin
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