Abstract | BACKGROUND: METHODS: We assessed FFA kinetics during basal conditions and during a hyperinsulinemic-euglycemic clamp procedure in 14 lean people and 46 people with obesity by using [13C] palmitate tracer infusion. Insulin-stimulated muscle glucose uptake rate was evaluated by dynamic PET-imaging of skeletal muscles after [ 18F]fluorodeoxyglucose injection. RESULTS: Plasma FFA clearance was accelerated in participants with obesity and correlated negatively with muscle insulin sensitivity without a difference between lean and obese participants. Furthermore, insulin infusion increased FFA clearance and the increase was greater in obese than lean participants. CONCLUSIONS: Our findings suggest plasma FFA extraction efficiency, not just plasma FFA concentration, is an important determinant of the cellular fatty acid load and the stimulatory effect of insulin on FFA clearance counteracts some of its antilipolytic effect.
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Authors | Chao Cao, Han-Chow E Koh, Stephan Van Vliet, Bruce W Patterson, Dominic N Reeds, Richard Laforest, Robert J Gropler, Bettina Mittendorfer |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 132
Pg. 155216
(07 2022)
ISSN: 1532-8600 [Electronic] United States |
PMID | 35577100
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2022. Published by Elsevier Inc. |
Chemical References |
- Fatty Acids
- Fatty Acids, Nonesterified
- Insulin
- Glucose
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Topics |
- Fatty Acids
(metabolism)
- Fatty Acids, Nonesterified
- Glucose
(metabolism)
- Humans
- Insulin
(metabolism)
- Insulin Resistance
(physiology)
- Kinetics
- Muscle, Skeletal
(metabolism)
- Obesity
(metabolism)
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