PRAME Is a Potential Carcinogenic Biomarker that Correlates with Patient Prognosis and Tumor Immunity Based on Pan-Cancer Analysis.

Abstract

OBJECTIVE:

This study was designed to visualize the pan-cancer prognostic significance of PReferentially expressed Antigen in Melanoma (PRAME) and investigate the relationship between PRAME expression and tumor immunity.

MATERIAL AND METHODS:

We explored the expression patterns and prognostic value of PRAME across multiple cancers using data from the Cancer Genome Atlas, Genotype-Tissue Expression, and Cancer Cell Line Encyclopedia databases. Spearman's correlation test was used to evaluate correlations between PRAME expression and the tumor immune microenvironment, mutation indicators, and DNA methylation. Finally, the functions of PRAME and potential signaling pathway mechanisms were explored through Gene Set Enrichment Analysis (GSEA).

RESULTS:

Pan-cancer survival analysis indicated that PRAME was widely up-regulated in most tumors, and its high expression was indicative of poor overall survival in different cancer types. In addition, PRAME expression levels were strongly linked to immune infiltration, immune score, immune checkpoint, immune neoantigens, tumor mutation burden, microsatellite instability, mismatch repair, and DNA methyltransferase in a variety of cancers. GSEA analysis revealed that PRAME was related to the regulation of numerous signaling pathways implicated in tumor immunity and tumorigenicity.

CONCLUSIONS:

PRAME has the potential to serve as a prognostic pan-cancer biomarker and is correlated with tumor immunity. Its use may help shed light on optimum cancer therapies.

• Authors: Qi Zhao, Zhongwei Zhang, Yinfang Wu
• Journal: Annals of clinical and laboratory science (Ann Clin Lab Sci) Vol. 52 Issue 2 Pg. 185-195 (Mar 2022) ISSN: 1550-8080 [Electronic] United States
• PMID: 35414497 (Publication Type: Journal Article)
• Copyright: © 2022 by the Association of Clinical Scientists, Inc.

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Carcinogens
• PRAME protein, human

Topics

• Antigens, Neoplasm (genetics)
• Biomarkers, Tumor (genetics)
• Carcinogenesis (genetics)
• Carcinogens
• Humans
• Neoplasms (metabolism)
• Prognosis
• Tumor Microenvironment (genetics)