Metastatic involvement of the umbilicus as a result of a visceral
carcinoma is a rare entity known as
Sister Mary Joseph's nodule (SMJN). The most common primary sites are the gastrointestinal and gynecological tract. The occurrence of SMJN is commonly associated with advanced
peritoneal disease and poor prognosis. The average survival time at the appearance of an umbilical
metastasis is estimated
at 10 months, and only 13% of patient will be alive at 2 years. Treatment usually involves systemic
chemotherapy and
palliative care, but the possibility of surgical resection should be considered especially if good response to systemic treatment is achieved in selected patients to maintain or to improve the quality of life. We describe here an unusual case of a 60-year-old man referred with enlarging umbilical lesion, identified as SMJN, that was metastasized from advanced
signet ring cell carcinoma of the stomach with generalized
peritoneal carcinomatosis. The nodule had rapid progression, and in a few days had reached 15 cm.
Chemotherapy was started immediately and patient achieved good clinical and radiological response. A resection of the umbilical nodule was discussed but the patient unfortunately died following a massive
pulmonary embolism. This case is unique in view of the unusual size of the SMJN in our patient and the good response to
chemotherapy. We present this case to increase physician's awareness for careful evaluation of the umbilical area and encourage them to look for a primary digestive
tumor if an umbilical nodule is observed. Therapeutic response to primary
chemotherapy may encourage a multimodal approach allowing resectability of the metastatic umbilical nodule.