Abstract | BACKGROUND AND OBJECTIVES: DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The 28 patients and their kidney biopsies were included when polyvinylpyrrolidone deposition was recognized, either retrospectively or at the time of diagnostic evaluation. Biopsies were taken between 2009 and 2016. We collected laboratory parameters and clinical data from digital patient charts. For each kidney biopsy, the glomerular volume, extent of polyvinylpyrrolidone deposition, and tubulointerstitial area with tubular atrophy were assessed quantitatively. RESULTS: All patients (mean age: 37 years) had CKD (mean eGFR: 33 ml/min per 1.73 m2) and normal urine protein or non-nephrotic-range proteinuria. Biopsies showed moderate to severe tubular atrophy (mean extent: 65%) and interstitial infiltrates of vacuolated macrophages containing polyvinylpyrrolidone (mean share of biopsy area: 1.5%). Underperfused and ischemic glomeruli were common findings. In 22 samples, ultrastructural investigation revealed polyvinylpyrrolidone-containing vacuoles in the mesangial or endothelial cells of glomeruli. At the last follow-up, most patients had stable or improved eGFR. Two patients had developed kidney failure and underwent hemodialysis. CONCLUSIONS:
|
Authors | Ida V Stalund, Heidi Grønseth, Finn P Reinholt, Einar Svarstad, Hans-Peter Marti, Sabine Leh |
Journal | Clinical journal of the American Society of Nephrology : CJASN
(Clin J Am Soc Nephrol)
Vol. 17
Issue 4
Pg. 518-526
(04 2022)
ISSN: 1555-905X [Electronic] United States |
PMID | 35296512
(Publication Type: Journal Article)
|
Copyright | Copyright © 2022 by the American Society of Nephrology. |
Chemical References |
|
Topics |
- Adult
- Atrophy
(pathology)
- Biopsy
- Endothelial Cells
(pathology)
- Humans
- Kidney
(pathology)
- Methadone
- Opioid-Related Disorders
(complications, pathology)
- Povidone
(adverse effects)
- Renal Insufficiency, Chronic
(chemically induced, etiology, pathology)
- Retrospective Studies
|