Methadone (Dolophine)

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2213 relevant articles (158 outcomes, 322 trials/studies) found for this Drug

Description: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Also Known As:

Dolophine; Methadose; Amidone; Biodone; Biomet Brand of Methadone Hydrochloride; Esteve Brand of Methadone Hydrochloride; Generics Brand of Methadone Hydrochloride; GlaxoSmithKline Brand of Methadone Hydrochloride; Mallinckrodt Brand of Methadone Hydrochloride; Martindale Brand of Methadone Hydrochloride; Metadol; Metasedin; Methaddict; Methadone Hydrochloride; Methex; Pharmascience Brand of Methadone Hydrochloride; Phenadone; Phymet; Physeptone; Pinadone; Pinewood Brand of Methadone Hydrochloride; Rosemont Brand of Methadone Hydrochloride; Roxane Brand of Methadone Hydrochloride; Symoron; Yamanouchi Brand of Methadone Hydrochloride; addiCare Brand of Methadone Hydrochloride; Hydrochloride, Methadone; 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 42

2-formamido-4,4-diphenyl-5-heptanone

5-methylmethadone

6-dimethylamino-4-(4-hydroxyphenyl)-4-phenylheptan-3-one

Experts

1.	Adelson, Miriam: 6 articles (07/2008 - 01/2004)
2.	Kreek, Mary Jeanne: 6 articles (07/2008 - 01/2002)
3.	Bruera, Eduardo: 5 articles (06/2008 - 02/2002)
4.	Petry, Nancy M: 4 articles (02/2006 - 04/2005)
5.	Krantz, Mori J: 4 articles (04/2005 - 09/2002)
6.	Mehler, Philip S: 4 articles (04/2005 - 09/2002)
7.	Borg, Lisa: 3 articles (07/2008 - 01/2002)
8.	Peles, Einat: 3 articles (07/2008 - 02/2005)
9.	Heilig, Markus: 3 articles (07/2008 - 08/2003)
10.	Kakko, Johan: 3 articles (07/2008 - 08/2003)

Related Diseases

1.	Pain (Aches) 11/01/2005 - "The randomized trial demonstrated a statistically significant improvement in pain for methadone (20 mg/day) compared to placebo. " 01/01/2008 - "Though useful in the treatment of opioid dependence and chronic pain, methadone possesses high abuse potential and documented mortality risks. " 04/01/2006 - "RESULTS: At follow-up, the intervention group reported significantly greater overall physician satisfaction (P=.002), including subscales on relationship quality (P=.03) and appropriate use of time (P=.02), self-reported completion rates of patient treatment agreements (P=.01), self-reported rates of methadone prescribing (P=.05), and self-reported change in care of patients with chronic pain (P=.01). " 06/01/2001 - "In the 10 patients who switched to methadone because of uncontrolled pain, a significant reduction in pain intensity (P <.005) and an average of a 33% increase in methadone doses necessary (P <.01) were found after an average of 3.5 days. " 03/01/2001 - "Treatment with oral methadone was successful and pain improved considerably. " Order ALL the reference details at left...
2.	Substance-Related Disorders (Drug Abuse) 09/18/1989 - "A significant minority of patients has benefited from methadone maintenance therapy, but most patients have continued their drug abuse and drug-related life-styles." 02/01/1977 - "It has been shown that while poor and middle class communities show good results with methadone maintenance approaches, in the area of secondary drug abuse they show marked dissimilarities. " 05/01/2002 - "In conclusion, INH retention time and completion rates were significantly improved by methadone treatment combined with observed INH, whether or not substance abuse counseling was provided. " 12/01/2008 - "AIMS: This study examines the efficacy of the Focus on Families project (currently called Families Facing the Future), a preventive intervention to reduce substance use disorders among children in families with a parent in methadone treatment. " 04/01/1998 - "AIMS: To provide empirically based evaluation data regarding the efficacy of psychopharmacological interventions in opiate substance abuse, the present study employed meta-analytic statistical procedures to determine the effectiveness of methadone hydrochloride as a pharmacotherapeutic agent. " Order ALL the reference details at left...
3.	Heroin Dependence (Heroin Abuse) 07/01/2006 - "CONCLUSIONS: The results confirm that, in a nonexperimental clinical practice setting, BUP is as effective as methadone in the treatment of heroin dependence, with significantly better opiate abuse control, thus possibly allowing longer and more effective treatment programs with reduced relapse rates." 06/01/2008 - "Heat and pain thresholds were measured by quantitative sensory testing (QST) in 23 subjects with heroin dependence in full, sustained remission months after detoxification from methadone and 27 healthy non-drug using controls. " 09/01/2005 - "STUDY OBJECTIVES: Methadone, a long-acting mu-opioid agonist, is an effective treatment for heroin addiction. " 07/15/2008 - "ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence." 03/01/2007 - "Methadone maintenance therapy has been the mainstay of treatment for heroin addiction since the 1970s. " Order ALL the reference details at left...
4.	Opioid-Related Disorders (Opiate Addiction) 10/01/2000 - "Reviews issued by the Institute of Medicine and the National Institutes of Health have defined narcotic addiction as a chronic medical disorder and have claimed that methadone maintenance coupled with social services is the most effective treatment for this condition. " 03/20/1991 - "Despite methadone treatment having been found effective in cases of opiate-dependence, and in many cases a prerequisite of rehabilitation, the queues for it are very long in Sweden--up to two years. " 01/01/2001 - "The new proposal for rule making (NPRM) will help the medical profession accept methadone treatment as beneficial for opiate addiction and realize that it should be more accessible to patients from trained physicians in the community. " 09/01/2005 - "For over 35 years, methadone maintenance therapy has been an effective treatment for opiate dependence; however, its use among opiate-dependent inmates in the United States is limited. " 01/01/1997 - "Although methadone maintenance is an effective treatment for opiate addiction, variations in treatment outcome are evident. " Order ALL the reference details at left...
5.	Neoplasms (Cancer) 09/01/2008 - "The objective of this study is to describe methadone use as primary opioid analgesic for advanced pediatric cancer over a 6.5-year period. " 09/01/2008 - "PROCEDURE: All 17 patients who received methadone as their primary opioid analgesic through the Northern Alberta Children's Cancer Program from January 2000 to June 2007 were included. " 09/01/2008 - "BACKGROUND: Methadone is frequently used in the treatment of adults with advanced cancer. " 02/01/2002 - "In some patients with cancer the long half-life of methadone offers the advantage of extended dosing intervals to 12 and even 24 hours, further research is also needed in this area." 11/01/1999 - "Eleven of 29 patients (38%) failed methadone due to rapidly progressive cancer, dose-limiting side effects, or other reasons, but the other patients were successfully rotated to methadone. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Buprenorphine (Subutex)
3.	Heroin (Diamorphine)
4.	Opioid Analgesics (Opioids)
5.	Cocaine (Cocaine HCl)
6.	Fentanyl (Sublimaze)
7.	2-methylcyclopentadienyl manganese tricarbonyl (MMT)
8.	Opioid Receptors (Opioid Receptor)
9.	Desipramine (Pertofrane)
10.	Meperidine (Pethidine)

Related Therapies and Procedures

1.	Analgesia
2.	Intravenous Anesthesia
3.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
4.	Anesthesia
5.	Condoms (Condom)

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