Ninety Years of Pentamidine: The Development and Applications of Pentamidine and its Analogs.

Abstract

Pentamidine, an FDA-approved human drug for many protozoal infections, was initially synthesized in the late 1930s and first reported to be curative for parasitosis in the 1940s. After ninety years of sometimes quiet growth, pentamidine and its derivatives have gone far beyond antibacterial agents, including but not limited to the ligands of DNA minor groove, modulators of PPIs (protein-protein interactions) of the transmembrane domain 5 of lateral membrane protein 1, and the blockers of the SARS-CoV-2 3a channel. This mini-review highlights the development and applications of pentamidine and its analogs, aiming to provide insights for further developing pentamidine derivatives in the following decades.

• Authors: Bo Zhang, Yushan Jin, Lei Zhang, Hongshuang Wang, Xiaohui Wang
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 29 Issue 26 Pg. 4602-4609 ( 2022) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 35289252 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Ligands
• Pentamidine
• DNA

Topics

• DNA (metabolism)
• Humans
• Ligands
• Pentamidine (pharmacology, therapeutic use)
• SARS-CoV-2
• COVID-19 Drug Treatment