Pentamidine (NebuPent)

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879 relevant articles (73 outcomes, 88 trials/studies) found for this Drug

Description: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.

Also Known As:

NebuPent; Pentam; Pentamidine Isethionate; Pentacarinat; American Pharmaceutical Partners Brand 1 of Pentamidine Isethionate; American Pharmaceutical Partners Brand 2 of Pentamidine Isethionate; Aventis Brand of Pentamidine Isethionate; Diamidine; GlaxoSmithKline Brand of Pentamidine Isethionate; JHC Brand of Pentamidine Isethionate; Lomidine; Pentamidin; Pentamidine Mesylate; Rhône-Poulenc Rorer Brand of Pentamidine Isethionate; Sicor Brand of Pentamidine Isethionate; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 40

Amidines: 8

Benzamidines: 2

Pentamidine: 879

1,3-di(4-imidazolinophenoxyl)propane: 7

butamidine: 3

platinum(II) pentamidine: 3

1,3-di-(4-imidazolino-2-methoxyphenoxy)propane: 2

butenamidine

cis-platinum pentamidine bromide

cis-platinum pentamidine seleniocyanate

cis-platinum pentamidine thiocyanate

gamma-oxapentamidine

methoxypentamidine isethionate

N,N'-dihydroxypentamidine

N-hydroxypentamidine

Experts

1.	Nacher, M: 2 articles (12/2002 - 06/2001)
2.	Guibert, P: 2 articles (12/2002 - 06/2001)
3.	Sainte Marie, D: 2 articles (12/2002 - 06/2001)
4.	Clyti, E: 2 articles (12/2002 - 06/2001)
5.	Couppié, P: 2 articles (12/2002 - 06/2001)
6.	Pradinaud, R: 2 articles (12/2002 - 06/2001)
7.	Carme, B: 2 articles (12/2002 - 06/2001)
8.	Chan, C K: 2 articles (06/2002 - 05/2001)
9.	Manfredi, Roberto: 1 article (06/2008)
10.	Calza, Leonardo: 1 article (06/2008)

Related Diseases

1.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 03/01/1991 - "Our retrospective study for ultrasonic nebulised pentamidine in 13 patients shows that 7 of 8 patients with Pneumocystis carinii pneumonia (PCP), proven by biopsy examination, were cured (recovery rate, 88%)" 04/01/1990 - "Two patients on suspicion of beginning pneumocystis carinii pneumonia improved their clinical and radiological state with higher dosages of pentamidine" 05/01/1994 - "The therapeutic efficacy of nebulised pentamidine in the prophylaxis of Pneumocystis carinii pneumonia (PCP) depends on the absolute pulmonary deposition of the drug" 06/01/1990 - "We have recently demonstrated that substitution of imidazoline moieties for the amidine groups of pentamidine produces a molecule that is effective against rat Pneumocystis carinii pneumonia and that is apparently less toxic than pentamidine" 07/01/1989 - "Pentamidine is effective in both the treatment and the prevention of Pneumocystis carinii pneumonia" Order ALL the reference details at left...
2.	Acquired Immunodeficiency Syndrome (AIDS) 06/01/1991 - "CONCLUSION: Intermittent therapy with aerosol pentamidine is highly effective and well tolerated as secondary prophylaxis for AIDS-related P" 05/01/1993 - "As PcP prophylaxis with pentamidine aerosol is effective in patients with AIDS, we conducted a prospective trial with regular inhalations of pentamidine" 10/01/1992 - "Since the prophylaxis of PcP with pentamidine-aerosol proved to be effective in patients with AIDS, we conducted a prospective trial with regular inhalations of pentamidine" 04/01/1990 - "The sample size is too small to draw definitive conclusions concerning the efficacy of pentamidine aerosol in AIDS patients." 07/01/1994 - "METHODS: A total of 121 HIV-infected patients with CD4+ cell counts < or = 200 x 10(6)/l or an AIDS diagnosis were enrolled in a controlled study of aerosolized pentamidine as primary PCP prophylaxis" Order ALL the reference details at left...
3.	Cutaneous Leishmaniasis 06/01/2001 - "Although frequently associated with discomfort, the two-injection course, giving a total of 8 mg pentamidine isethionate/kg, appears to be an effective treatment for cutaneous leishmaniasis in French Guiana" 01/01/2000 - "CONCLUSION: Pentamidine isethionate is a safe and effective first-line treatment for Old World leishmaniasis" 06/15/2006 - "Efficacy of short-course intramuscular pentamidine isethionate treatment on Old World localized cutaneous leishmaniasis in 2 patients." 11/01/2005 - "For New World leishmaniasis, parenteral antimonials represent the first-line treatment in all forms except those caused by Leishmania guyanensis in which pentamidine is preferable" 05/01/2003 - "A comparative study between the efficacy of pentamidine isothionate given in three doses for one week and N-methil-glucamine in a dose of 20mgSbV/day for 20 days to treat cutaneous leishmaniasis]" Order ALL the reference details at left...
4.	Pneumonia (Pneumonitis) 03/01/1993 - "CONCLUSIONS: These results suggest that children probably require lower nebuliser pentamidine doses to produce lung pentamidine concentrations equivalent to those found to be effective for preventing P carinii pneumonia in adults using the Respirgard II nebuliser." 02/01/1989 - "4) Aerosolised pentamidine therapy is very useful for prophylaxis of Pc pneumonitis." 02/01/1993 - "STUDY OBJECTIVE: To determine the relative distribution of Pneumocystis carinii in the lungs of patients with P carinii pneumonia and to see the effect of aerosol pentamidine prophylaxis on this distribution" 11/15/1991 - "carinii pneumonia) as well as with 114 patients receiving inhaled pentamidine in a study of primary pneumocystis prophylaxis in patients infected with HIV" 06/01/1991 - "carinii pneumonia were diagnosed before the termination of the trial; 27 cases occurred among 78 patients receiving placebo and 5 occurred among 84 patients receiving aerosol pentamidine" Order ALL the reference details at left...
5.	Visceral Leishmaniasis (Kala Azar) 04/01/1949 - "Treatment of kala-azar with pentamidine isothionate; a study of 55 cases." 12/01/1997 - "Prophylaxis with monthly pentamidine was not useful in reducing relapses of visceral leishmaniasis." 11/01/1997 - "The activity of pentamidine-loaded nanoparticles was compared with that of free pentamidine in a BALB/c mice model of visceral leishmaniasis induced by Leishmania infantum" 02/01/1996 - "Pentamidine isethionate as secondary prophylaxis against visceral leishmaniasis in HIV-positive patients." 11/01/1992 - "This confirms prior findings in Kenyan patients with kala-azar, and indicates that this regimen is a valid alternative to antimonial compounds alone in the State of Bihar, where cases of kala-azar not responding to antimonial drugs and intolerant of pentamidine are increasingly recorded." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
2.	Dapsone
3.	Trimethoprim (Proloprim)
4.	Antimony
5.	Zidovudine (Retrovir)
6.	Thymidine Monophosphate (TMP)
7.	Sulfamethoxazole
8.	Pyrimethamine (Daraprim)
9.	Pentamidine (NebuPent)
10.	Amphotericin B (Amphotericin)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Nebulizers and Vaporizers (Inhaler)
5.	Chemoprevention

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