At present, there is no noninvasive
biomarker of renal
fibrosis. The potential diagnostic value of urinary exosome-derived
circRNAs from glomerular disease patients for renal
fibrosis is still uncertain. Here, we first detected the expression of hsa_circ_0008925 in TGF-β1-cultured HK-2 cell-derived exosomes. Secondly, we collected urine samples from 95 biopsy-proven glomerular disease patients and 34 healthy controls. The expression of hsa_circ_0008925 was analyzed, and the correlation with renal function and pathological changes was calculated. The receiver operating characteristic (ROC) curve for the diagnosis of renal
fibrosis was performed. The results showed that in exosomes derived from TGF-β1-cultured HK-2 cells, the expression of hsa_circ_0008925 was increased compared with normal cultured. Further, the expression level of hsa_circ_0008925 was increased in urinary exosomes from renal
fibrosis patients and correlated with serum
creatinine, blood
urea nitrogen (BUN), estimated glomerular filtration rate, and
cystatin C. The level of hsa_circ_0008925 was furthermore correlated with the score of tubulointerstitial
fibrosis (TIF) and the score of glomerular
sclerosis. The ROC curve showed that hsa_circ_0008925 can diagnose renal
fibrosis at a cut-off value of 0.093 with a sensitivity of 52.2% and specificity of 96.4%. In summary, we indicated that urinary exosomal hsa_circ_0008925 could be acted as a noninvasive
biomarker for renal
fibrosis in glomerular diseases patients.