Anti-Inflammatory and Anti-Oxidant Activity of Ultra-Short Wave Diathermy on LPS-Induced Rat Lung Injury.

Abstract

We studied the lung-protective effect and mechanisms of the anti-inflammatory and antioxidant effects of ultra-short-wave diathermy (USWD) in a rat model of LPS-induced acute lung injury. Histological examination of the lung tissues was performed and the levels of oxidative stress-related factors and inflammatory cytokines were measured. It was shown that the lung injury score, the lung wet-to-dry weight ratio (W/D), oxidative stress-related factors malondialdehyde and acyl-CoA synthetase long-chain family member 4 (ACSL4), and inflammatory cytokines were increased after LPS administration, while USWD treatment reduced these parameters. In addition, superoxide dismutase and glutathione peroxidase 4 were decreased in rats with LPS-induced acute lung injury, while USWD therapy up-regulated the expression of these enzymes. Thus, USWD could antagonize lung injury by inhibiting oxidative stress and inflammatory response in rats with acute lung injury. USWD can be a promising adjunctive treatment to counter oxidative stress and inflammation and a potential therapeutic candidate for the treatment of patients with this pathology.

• Authors: Q Wu, M Qu, P Zhong, Y Zeng, J Wang, Q Zhang, Ting Wang, D Liu, L Yang, J Zhou, Tong Wang
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 172 Issue 4 Pg. 423-429 (Feb 2022) ISSN: 1573-8221 [Electronic] United States
• PMID: 35175488 (Publication Type: Journal Article)
• Copyright: © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Lipopolysaccharides

Topics

• Acute Lung Injury (drug therapy, therapy)
• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Antioxidants (metabolism)
• Diathermy
• Humans
• Lipopolysaccharides (pharmacology)
• Lung
• Oxidative Stress
• Radio Waves
• Rats