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Coenzyme A Ligases (Acid-Thiol Ligases)

Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1.
Also Known As:
Acid-Thiol Ligases; Co A Ligases; A Ligase, Coenzyme; A Synthetase, Coenzyme; Acid Thiol Ligases; CoA Synthetase, Acyl; CoA Synthetases, Acyl; Ligase, Coenzyme A; Ligases, Acid-Thiol; Ligases, Co A; Ligases, Coenzyme A; Synthetase, Acyl CoA; Synthetase, Coenzyme A; Synthetases, Acyl CoA; Synthetases, Coenzyme A; Acyl CoA Synthetase; Acyl CoA Synthetases; Acyl Coenzyme A Synthetase; Acyl Coenzyme A Synthetases; Coenzyme A Ligase; Coenzyme A Synthetase; Coenzyme A Synthetases
Networked: 197 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Maloberti, Paula M: 6 articles (03/2021 - 11/2010)
2. Coleman, Rosalind A: 6 articles (04/2013 - 01/2006)
3. Orlando, Ulises D: 5 articles (03/2021 - 11/2010)
4. Dattilo, Melina A: 4 articles (03/2021 - 12/2015)
5. Ramírez de Molina, Ana: 4 articles (12/2020 - 11/2015)
6. Reglero, Guillermo: 4 articles (12/2020 - 11/2015)
7. Sánchez-Martínez, Ruth: 4 articles (12/2020 - 11/2015)
8. Cruz-Gil, Silvia: 4 articles (01/2019 - 11/2015)
9. Rapoport, Stanley I: 4 articles (12/2014 - 12/2008)
10. Li, Lei O: 4 articles (04/2013 - 03/2010)

Related Diseases

1. Bipolar Disorder (Manic Depressive Psychosis)
2. Neoplasms (Cancer)
3. Breast Neoplasms (Breast Cancer)
4. Inflammation (Inflammations)
01/01/2022 - "RNA-seq analysis for differentially expressed genes (DEGs) reported Acyl-CoA synthetase long-chain family member 4 (ACSL4) related to ferroptosis and inflammation in I/R mice renal, which was validated in rodent renal. "
08/02/2023 - "Further molecular docking suggested that linoleic acid can bind to the acyl-CoA synthetase 1 (ACSL1) protein, which has been shown to be associated with multiple inflammatory diseases and is an upstream regulator of the MAPK and NF-κB signaling pathways that mediate inflammation. "
04/01/2015 - "The expression of specific acyl-CoA synthetase, lysophospholipid acyltransferase and phospholipase A2 isotypes has recently been shown to have an impact on membrane PUFA content, on the production of lipid mediators and on inflammation. "
11/06/2023 - "Compared to the LCM group, the expression of genes associated with ferroptosis and inflammation, including acyl-CoA synthetase long-chain family member 4b (acsl4b), lysophosphatidylcholine acyltransferase 3 (lpcat3), cyclooxygenase (cox), interleukin 1β (il-1β), and nuclear factor kappa b (nfκb), were significantly increased in the HCM group (p < 0.05), whereas Fe2+ supplementation in the HCM diet significantly inhibited their expression (p < 0.05) and significantly suppressed lipoxygenase (lox) expression (p < 0.05). "
01/01/2021 - "Also, Eto inhibited IR-induced ferroptosis in myocardium, including reducing superoxide dismutase content, glutathione activity, and glutathione peroxidase 4 expression, while increasing the levels of malondialdehyde and iron and Acyl-CoA synthetase long-chain family member 4. Moreover, the inhibition of Eto on IR-induced myocardial fibrosis and inflammation could be eliminated by erastin. "
5. Fibrosis (Cirrhosis)

Related Drugs and Biologics

1. Acetyl-CoA Carboxylase
2. Phospholipid Hydroperoxide Glutathione Peroxidase
3. Iron
4. Arachidonic Acid (Vitamin F)
5. Phospholipids (Phosphatides)
6. Glutathione (Reduced Glutathione)
7. Phosphoenolpyruvate
8. Malondialdehyde (Propanedial)
9. Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)
10. Valproic Acid (Depakote)

Related Therapies and Procedures

1. Caloric Restriction
2. Highly Active Antiretroviral Therapy (HAART)
3. Cardiopulmonary Resuscitation (CPR)
4. Gastrectomy
5. Diet Therapy (Therapy, Diet)