Abstract | BACKGROUND: DESIGN AND METHODS: We used a two-stage hyperinsulinemic-euglycemic clamp procedure in conjunction with stable isotopically labeled glucose and palmitate tracer infusions and 18F-fluorodeoxyglucose injection and positron emission tomography to quantify multi-organ insulin action and oral and intravenous tolerance tests to evaluate glucose-stimulated insulin secretion in fifteen people with obesity and OSA and thirteen people with obesity without OSA. RESULTS: OSA was associated with marked insulin resistance of adipose tissue triglyceride lipolysis and glucose uptake into both skeletal muscles and adipose tissue, whereas there was no significant difference between the OSA and control groups in insulin action on endogenous glucose production, basal insulin secretion, and glucose-stimulated insulin secretion during both intravenous and oral glucose tolerance tests. CONCLUSIONS:
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Authors | Han-Chow E Koh, Stephan van Vliet, Chao Cao, Bruce W Patterson, Dominic N Reeds, Richard Laforest, Robert J Gropler, Yo-El S Ju, Bettina Mittendorfer |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 186
Issue 4
Pg. 457-467
(Feb 23 2022)
ISSN: 1479-683X [Electronic] England |
PMID | 35118996
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adult
- Blood Glucose
(drug effects, metabolism)
- Diabetes Mellitus, Type 2
(blood, diagnosis, epidemiology)
- Female
- Glucose
(administration & dosage)
- Glucose Clamp Technique
(methods)
- Glucose Tolerance Test
(methods)
- Humans
- Insulin Resistance
(physiology)
- Male
- Middle Aged
- Obesity
(blood, diagnosis, epidemiology)
- Sleep Apnea, Obstructive
(blood, diagnosis, epidemiology)
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