Lean adolescents with insulin resistance display higher angiopoietin like protein 3, ApoC-III and chylomicron remnant dyslipidemia.

Abstract

BACKGROUND:

Triglyceride-rich lipoproteins (TRL: chylomicrons and VLDL) are a key component of diabetes dyslipoproteinemia and cardiovascular risk. We have shown that it is already prevalent in obese adolescents in association with lipoprotein lipase (LPL) dysregulation. Insulin resistance (IR) suffices to produce TRL dyslipoproteinemia and LPL dysfunction even in the absence of obesity.

METHODS:

This cross-sectional study included euglycemic adolescents between 15 and 19 y, classified in 4 groups according to BMI, HOMA-IR and fasting lipid as: metabolically healthy lean (MHL, n = 30), metabolically unhealthy lean (MUL, n = 25), metabolically healthy obese (MHO, = 30), and metabolically unhealthy obese (MUO, n = 42).

RESULTS:

As compared to MHL, MUL participants showed 73% higher concentrations of ApoB-48; 84% of ApoC-III; 24% ANGPTL-3; 200% of TG; 218% of VLDL-C and 238% of TG/HDL-C c, No changes were found in LPL mass. Interestingly, the differences in these parameters between MUL and MHO were not significant.

CONCLUSION:

Euglycemic lean adolescents with IR display TRL dyslipoproteinemia with increased inhibition of LPL as highlighted by higher concentrations of ANGPTL-3, ApoC-III and fasting chylomicron remnants (ApoB-48).

• Authors: Karla Paola Gutiérrez Castro, Alma Patricia González, Russell Caccavello, Ma Eugenia Garay-Sevilla, Alejandro Gugliucci
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 526 Pg. 43-48 (Feb 01 2022) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 34971570 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Angiopoietin-Like Protein 3
• Apolipoprotein C-III
• Chylomicron Remnants
• Triglycerides

Topics

• Adolescent
• Angiopoietin-Like Protein 3
• Apolipoprotein C-III
• Chylomicron Remnants
• Cross-Sectional Studies
• Dyslipidemias
• Humans
• Insulin Resistance
• Triglycerides