Chylomicrons

A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.

Also Known As:

Networked: 730 relevant articles (54 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Maranhão, Raul C: 15 articles (01/2020 - 04/2002)
2.	Tso, Patrick: 11 articles (10/2018 - 05/2005)
3.	Adeli, Khosrow: 10 articles (10/2017 - 02/2007)
4.	Yamashita, Shizuya: 9 articles (02/2017 - 06/2007)
5.	Maranhão, R C: 9 articles (03/2007 - 02/2000)
6.	Santos, Raul D: 8 articles (09/2021 - 04/2002)
7.	Davidson, Nicholas O: 7 articles (01/2021 - 05/2005)
8.	Lewis, Gary F: 7 articles (01/2020 - 01/2002)
9.	Watts, Gerald F: 7 articles (12/2016 - 02/2003)
10.	Hussain, M Mahmood: 6 articles (01/2022 - 05/2008)

Related Diseases

1.	Hypertriglyceridemia 02/01/1981 - "A few obese, hypothyroid patients with fasting hypertriglyceridemia had low clearance of chylomicrons, which may have been due in part to competition for removal of excess endogenous TG. " 02/01/1981 - "In hypothyroid patients without hypertriglyceridemia, clearance of chylomicrons was normal. " 04/01/2022 - "Primary chylomicronemia is characterized by pathological accumulation of chylomicrons in the plasma causing severe hypertriglyceridemia, typically >10 mmol/L (>875 mg/dL). " 05/01/2021 - "Chylomicronemia is characterized by severe hypertriglyceridemia when chylomicrons persist in plasma despite a fasting state. " 01/01/2020 - "Patients with FCS have loss of function of their LPL leading to severely elevated chylomicrons in the circulation and hence, severe hypertriglyceridemia. "
2.	Hyperlipidemias (Hyperlipidemia) 04/01/2000 - "Android obese patients with a fasting TG in the normal range and not different from the fasting TG of lean controls had an abnormal postprandial lipemia response, indicated by a significantly greater TG in the non-chylomicron subfraction than in controls. " 08/01/2018 - "Although postprandial lipidemia is increased in older subjects, the specific chylomicron metabolism has not been explored in older subjects nor compared to young subjects, which is the focus of this study. " 06/08/2019 - "Effect of Nutrient and Micronutrient Intake on Chylomicron Production and Postprandial Lipemia." 11/01/2018 - "This is the first report to attribute the retinal vessel color change to disrupted laminar flow and the intermixing of larger erythrocytes and smaller chylomicrons in a patient with lipemia retinalis. " 08/01/2015 - "Postprandial lipemia in mice can be modulated by emulsifying with MPLs compared with SPLs, partly through differences in chylomicron assembly, and TG hydrolysis rate as observed in vitro. "
3.	Insulin Resistance 12/01/2021 - "Furthermore, the associations between XXLVLDL response and insulinogenic index, HOMA-β, Matsuda insulin sensitivity index, and HbA1c in the NEO study implied the role of chylomicron synthesis in diabetes (with false discovery rate-corrected q <0.05). " 01/02/2015 - "Intestine-specific inhibitors of MTP decrease chylomicron biogenesis and improve insulin sensitivity in experimental animals and, while overcoming hepatic steatosis, may have significant gastrointestinal side effects that could limit their use in humans. " 05/07/2010 - "Enhanced chylomicron assembly and secretion has been documented in animal models of insulin resistance, but the underlying mechanistic factors are unknown. " 02/01/2009 - "Both insulin resistance and diabetes are associated with abnormalities in chylomicron production, and clearance and regulatory genes have been identified. " 10/01/2005 - "The change in postprandial chylomicron kinetics could not be explained by changes in insulin sensitivity, which appeared to be similar before and after intervention with either diet. "
4.	Type 2 Diabetes Mellitus (MODY) 01/01/2018 - "In type 2 diabetes mellitus there is an overproduction of chylomicron in the postprandial state that is associated with increased cardiovascular risk. " 04/01/2012 - "It is not currently known whether this acute effect on chylomicron production is similarly blunted in humans with type 2 diabetes. " 08/01/2010 - "Our objective was to evaluate whether the Ala54Thr polymorphism of the FABP2 gene influences the FA composition in chylomicrons after a standard meal in patients with type 2 diabetes. " 09/01/1996 - "Chylomicron clearance was impaired only in HTG-NIDDM patients (p < 0.05). " 07/01/2023 - "A patient with well-controlled type 2 diabetes mellitus (T2DM) and a heterozygote for lipoprotein lipase deficiency (HeLPL) presented with chronic chylomicrons (CMs). "
5.	Obesity 05/14/2010 - "The new rapid method facilitates large scale clinical and nutritional trials with inclusion of diagnostics of chylomicron status and thus creates new opportunities for research in lifestyle diseases and obesity." 01/01/2023 - "These results revealed that SEC16B plays important roles in chylomicron metabolism, which may shed light on the association between variants in SEC16B and obesity in human." 01/01/2023 - "Intestinal SEC16B modulates obesity by regulating chylomicron metabolism." 10/01/2022 - "LPS levels were 57% higher in the obesity-diabetes group (P < 0.001), but, contrary to the chylomicron transfer hypothesis, levels significantly declined following the high-fat challenge. " 10/01/2008 - "Taken together, our findings suggest that, in addition to other previously identified mechanisms of obesity, apolipoproteinE and possibly the chylomicron pathway are also important contributors to the development of obesity and related metabolic dysfunctions in mice."

Related Drugs and Biologics

1.	Triglycerides (Triacylglycerol)
2.	Lipids
3.	Lipoproteins (Lipoprotein)
4.	VLDL Lipoproteins
5.	Chylomicron Remnants
6.	Emulsions
7.	Chylomicrons
8.	oxidized low density lipoprotein
9.	Apolipoprotein B-48
10.	Cholesterol

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Renal Dialysis (Hemodialysis)
4.	Fat-Restricted Diet (Diet, Fat Restricted)
5.	Intravenous Administration