Abstract | BACKGROUND: OBJECTIVE: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. METHODOLOGY: RESULTS: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. CONCLUSION: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.
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Authors | Li Gao, Shasha Cui, Zhiqiang Huang, Hailong Cui, Tahani Awad Alahmadi, Velu Manikandan |
Journal | Saudi journal of biological sciences
(Saudi J Biol Sci)
Vol. 28
Issue 12
Pg. 7090-7097
(Dec 2021)
ISSN: 1319-562X [Print] Saudi Arabia |
PMID | 34867011
(Publication Type: Journal Article)
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Copyright | © 2021 The Author(s). |