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Diclofenac (SR 38)

A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Also Known As:

SR 38; Voltaren; Diclofenac Sodium; Voltarol; SR38; Dichlofenal; Diclofenac Potassium; Diclonate P; Dicrofenac; Feloran; GP-45,840; Novapirina; Orthofen; Orthophen; Ortofen; SR-38; Sodium Diclofenac; Diclofenac, Sodium; GP 45,840; GP45,840; Diclophenac; Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-

Networked: 2106 relevant articles (315 outcomes, 486 trials/studies) for this Drug, Comments

Relationship Network

Drug Context: Research Results

Experts

1.	Laine, Loren: 10 articles (06/2009 - 04/2002)
2.	Curtis, Sean P: 8 articles (06/2009 - 08/2006)
3.	Kaur, Amarjot: 6 articles (06/2009 - 11/2006)
4.	Cannon, Christopher P: 6 articles (06/2009 - 08/2006)
5.	Gold, Morris S: 5 articles (12/2009 - 01/2003)
6.	Granados-Soto, Vinicio: 5 articles (11/2008 - 02/2002)
7.	Reyes-García, Gerardo: 5 articles (01/2008 - 01/2003)
8.	Roth, Joachim: 5 articles (07/2007 - 01/2002)
9.	Hübschle, Thomas: 5 articles (07/2007 - 01/2002)
10.	Gerstberger, Rüdiger: 5 articles (07/2007 - 01/2002)

Related Diseases

1.	Pain (Aches) 05/01/1991 - "Physician's assessment of complete relief of pain was also statistically significant (P less than 0.01) in favour of Voltaren Emulgel throughout the trial period and the physician's overall assessment of therapeutic efficacy revealed that a satisfactory result was achieved in 86% of Voltaren Emulgel-treated patients compared with 76% of patients receiving regular gel (P less than 0.05). " 05/01/1999 - "Diclofenac-potassium is a potent NSAID available as a fast-acting oral tablet, which has been shown to be safe and effective in several other acute pain indications. " 01/01/2008 - "* Single-dose HPbetaCD diclofenac 3.75, 9.4, 18.75, 25, 37.5, 50 and 75 mg administered by intravenous bolus injection produced significantly greater responses than placebo for total pain relief (TOTPAR) over 6 hours or pain intensity at 4 hours in the treatment of moderate or severe postoperative dental pain in randomized, double-blind trials. " 12/01/2005 - "At the end of the study, patients rated diclofenac gel as significantly more effective in treating the pain of OA of the knee (p = 0.03) compared to placebo. " 03/01/2001 - "No significant reduction in pain score with diclofenac was seen at any of the assessments during the study period. " Order ALL the reference details at left...
2.	Osteoarthritis 11/20/2004 - "CONCLUSIONS: Acupuncture plus diclofenac is more effective than placebo acupuncture plus diclofenac for the symptomatic treatment of osteoarthritis of the knee." 01/01/1991 - "The results of this 4-week study thus demonstrate that diclofenac dispersible is not only effective in treating osteoarthritis in the elderly but also has an acceptable tolerability profile in a patient population which is especially vulnerable to adverse effects induced by non-steroidal anti-inflammatory drugs." 09/01/1996 - "Effective treatment of osteoarthritis with a 150 mg prolonged-release of diclofenac sodium." 04/28/1986 - "The results of this review document that diclofenac is as effective as other nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis." 12/13/2004 - "The purpose of this study was to compare the efficacy of DJW versus diclofenac in symptomatic treatment of osteoarthritis (OA) of the knee. " Order ALL the reference details at left...
3.	Rheumatoid Arthritis 01/01/1986 - "Diclofenac was found to be effective, safe, and well tolerated for the treatment of patients with active rheumatoid arthritis." 01/01/2008 - "Enhanced efficacy of diclofenac sodium-loaded lipogelosome formulation in intra-articular treatment of rheumatoid arthritis." 01/01/1988 - "Comparative pharmacokinetic and pharmacodynamic studies on ortophen, a new Soviet antiinflammatory drug, and voltaren (Ciba-Geigy, Switzerland) were carried out in 73 patients with rheumatoid arthritis. " 01/01/1986 - "Double-blind randomized trial of diclofenac sodium versus placebo in patients with rheumatoid arthritis." 01/01/1978 - "A study of the anti-inflammatory effect of Voltaren in patients with rheumatoid arthritis." Order ALL the reference details at left...
4.	Postoperative Pain 01/01/1987 - "Efficacy of diclofenac in a single prophylactic dose in postoperative pain." 12/01/1991 - "A randomised, controlled study was undertaken to assess the postoperative pain and side effects experienced by patients undergoing day case diagnostic laparoscopy and laparoscopic sterilisation, and to evaluate the effectiveness in these patients of peroperative diclofenac. " 08/01/1985 - "The study indicates that visual analogue scales may also be useful in assessment of swelling and that Voltaren in a fixed dosage offers a promising alternative against postoperative pain and swelling." 01/01/2009 - "AUTHORS' CONCLUSIONS: Oral diclofenac is an effective single-dose treatment for moderate to severe postoperative pain. " 01/01/2009 - "OBJECTIVES: To assess single dose oral diclofenac for the treatment of acute postoperative pain. " Order ALL the reference details at left...
5.	Inflammation 08/01/2003 - "METHODS: This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via estimates of mechanical pain thresholds obtained at the site of induced inflammation with von Frey hairs. " 01/01/1986 - "A useful model that combines paracentesis with administration of a leukotactic factor was developed in order to study the effects of topical diclofenac sodium on various aspects of ocular inflammation. " 12/01/2009 - "Such nanocomposites possessed very important characteristics such as unusually high drug loading, enhanced magnetic susceptibility and prolonged drug release, indicating their potential use as nanocarriers for efficient delivery of diclofenac sodium to inflammation sites." 11/01/2009 - "CONCLUSIONS AND CLINICAL RELEVANCE: Topical application of 1% diclofenac sodium liposomal cream to sites of IVRLP in healthy horses decreased inflammation as judged by visual assessment and ultrasonography. " 11/01/2009 - "OBJECTIVE: To determine whether topical application of 1% diclofenac sodium cream would decrease inflammation at sites of IV regional limb perfusion (IVRLP) in healthy horses. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Naproxen (Naprosyn)
3.	Diclofenac (SR 38)
4.	Ibuprofen (Motrin)
5.	Acetaminophen (Paracetamol)
6.	Piroxicam (Feldene)
7.	celecoxib (Celebrex)
8.	Aspirin (Acetylsalicylic Acid)
9.	Misoprostol (Cytotec)
10.	rofecoxib (Vioxx)

Related Therapies and Procedures

1.	Phacoemulsification
2.	Intraocular Lens Implantation
3.	Analgesia
4.	Injections
5.	Tonsillectomy

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